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- W2073225954 endingPage "402" @default.
- W2073225954 startingPage "394" @default.
- W2073225954 abstract "Chronic, excessive exposure to manganese (Mn) may induce neurotoxicity and cause an irreversible brain disease, referred to as manganism. Efficacious therapies for the treatment of Mn are lacking, mandating the development of new interventions. The purpose of the present study was to investigate the efficacy of ebselen (Ebs) and para-aminosalicylic acid (PAS) in attenuating the neurotoxic effects of Mn in an in vivo rat model. Exposure biomarkers, inflammatory and oxidative stress biomarkers, as well as behavioral parameters were evaluated. Co-treatment with Mn plus Ebs or Mn plus PAS caused a significant decrease in blood and brain Mn concentrations (compared to rats treated with Mn alone), concomitant with reduced brain E2 prostaglandin (PGE2) and enhanced brain glutathione (GSH) levels, decreased serum prolactin (PRL) levels, and increased ambulation and rearing activities. Taken together, these results establish that both PAS and Ebs are efficacious in reducing Mn body burden, neuroinflammation, oxidative stress and locomotor activity impairments in a rat model of Mn-induced toxicity." @default.
- W2073225954 created "2016-06-24" @default.
- W2073225954 creator A5021998308 @default.
- W2073225954 creator A5028058244 @default.
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- W2073225954 creator A5052402275 @default.
- W2073225954 creator A5056087320 @default.
- W2073225954 creator A5070219261 @default.
- W2073225954 date "2012-02-01" @default.
- W2073225954 modified "2023-09-26" @default.
- W2073225954 title "Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity" @default.
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