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- W2073228013 endingPage "1471" @default.
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- W2073228013 abstract "Precursor-directed biosynthesis was used to produce analogues of the cyclic depsipeptide mycotoxin beauvericin (1) using the filamentous fungus Beauveria bassiana ATCC 7159. Feeding 30 analogues of d-2-hydroxyisovalerate and l-phenylalanine, the natural 2-hydroxycarboxylic acid and amino acid precursors of beauvericin, led to the biosynthesis of novel beauvericins. Six of these were isolated and characterized, and their cytotoxicity and directional cell migration (haptotaxis) inhibitory activity against the metastatic prostate cancer cell line PC-3M were evaluated. Replacement of one, two, or all three of the d-2-hydroxyisovalerate constituents in beauvericin (1) with 2-hydroxybutyrate moieties (beauvericins G1–3, compounds 2–4) caused a parallel decline of cell migration inhibitory activity and cytotoxicity, suggesting a requirement for a branched side chain for both of these biological activities at the corresponding positions of beauvericins. Replacement of one, two, or all three N-methyl-l-phenylalanine residues of beauvericin with N-methyl-l-3-fluorophenylalanine moieties (beauvericins H1–3, compounds 5–7) increased cytotoxicity without affecting antihaptotactic activity." @default.
- W2073228013 created "2016-06-24" @default.
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- W2073228013 date "2007-09-01" @default.
- W2073228013 modified "2023-09-28" @default.
- W2073228013 title "Cytotoxic and Antihaptotactic Beauvericin Analogues from Precursor-Directed Biosynthesis with the Insect Pathogen <i>Beauveria bassiana</i> ATCC 7159" @default.
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- W2073228013 doi "https://doi.org/10.1021/np070262f" @default.
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