FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073228346> ?p ?o ?g. }

• W2073228346 abstract "The development of multidrug resistance (MDR) causes problems in the chemotherapy of human cancer. The present study was designed to evaluate and establish the role of Eclipta alba as MDR reversal agent using multidrug resistant hepatocellular carcinoma cell line (DR-HepG2). To develop DR-HepG2, hepatocellular carcinoma cell line (HepG2) was transfected with 2-Acetylaminofluorene (AAF) and Aflatoxin B1 (AFB). Cytotoxic effects of the Eclipta alba hydroalcoholic extract (EAE) and standard anti-ancer drug Doxorubicin (DOX) were determined in DR-HepG2 and the parental cells HepG2 using MTT assay. The expression level of MDR1 gene and P-glycoprotein (P-gp) level was analyzed by RT-PCR and western blotting. From the present investigation, it was found that EAE (10 and 20 μg/ml) could significantly inhibit cell proliferation in DR-HepG2 whereas DOX (0.5 μg/ml) could not because of enhancement effect of MDR1/P-gp. This study demonstrated for the first time the antiproliferative activities of EAE in multidrug resistant DR-HepG2 cells. The findings revealed that Eclipta alba components are effective inhibitors of MDR1/P-gp." @default.
• W2073228346 created "2016-06-24" @default.
• W2073228346 creator A5051963822 @default.
• W2073228346 creator A5071796211 @default.
• W2073228346 creator A5090289705 @default.
• W2073228346 date "2013-07-01" @default.
• W2073228346 modified "2023-09-24" @default.
• W2073228346 title "Evaluation of Hydro-Alcoholic Extract ofEclipta albafor its Multidrug Resistance Reversal Potential: An In Vitro Study" @default.
• W2073228346 cites W1965660130 @default.
• W2073228346 cites W1972522031 @default.
• W2073228346 cites W1973522717 @default.
• W2073228346 cites W2007662671 @default.
• W2073228346 cites W2016446817 @default.
• W2073228346 cites W2036625190 @default.
• W2073228346 cites W2038546265 @default.
• W2073228346 cites W2038758400 @default.
• W2073228346 cites W2050767955 @default.
• W2073228346 cites W2060293769 @default.
• W2073228346 cites W2061292851 @default.
• W2073228346 cites W2088629624 @default.
• W2073228346 cites W2098142549 @default.
• W2073228346 cites W2114915163 @default.
• W2073228346 cites W2123773797 @default.
• W2073228346 cites W2128340527 @default.
• W2073228346 cites W2169302611 @default.
• W2073228346 cites W4293247451 @default.
• W2073228346 cites W84182309 @default.
• W2073228346 doi "https://doi.org/10.1080/01635581.2013.789116" @default.
• W2073228346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23859045" @default.
• W2073228346 hasPublicationYear "2013" @default.
• W2073228346 type Work @default.
• W2073228346 sameAs 2073228346 @default.
• W2073228346 citedByCount "10" @default.
• W2073228346 countsByYear W20732283462013 @default.
• W2073228346 countsByYear W20732283462014 @default.
• W2073228346 countsByYear W20732283462015 @default.
• W2073228346 countsByYear W20732283462016 @default.
• W2073228346 countsByYear W20732283462017 @default.
• W2073228346 countsByYear W20732283462019 @default.
• W2073228346 crossrefType "journal-article" @default.
• W2073228346 hasAuthorship W2073228346A5051963822 @default.
• W2073228346 hasAuthorship W2073228346A5071796211 @default.
• W2073228346 hasAuthorship W2073228346A5090289705 @default.
• W2073228346 hasConcept C114851261 @default.
• W2073228346 hasConcept C126322002 @default.
• W2073228346 hasConcept C133936738 @default.
• W2073228346 hasConcept C154317977 @default.
• W2073228346 hasConcept C202751555 @default.
• W2073228346 hasConcept C2776694085 @default.
• W2073228346 hasConcept C2778019345 @default.
• W2073228346 hasConcept C2778707650 @default.
• W2073228346 hasConcept C2780783641 @default.
• W2073228346 hasConcept C2781303535 @default.
• W2073228346 hasConcept C502942594 @default.
• W2073228346 hasConcept C54355233 @default.
• W2073228346 hasConcept C55493867 @default.
• W2073228346 hasConcept C556039675 @default.
• W2073228346 hasConcept C71924100 @default.
• W2073228346 hasConcept C81885089 @default.
• W2073228346 hasConcept C86803240 @default.
• W2073228346 hasConcept C89423630 @default.
• W2073228346 hasConcept C98274493 @default.
• W2073228346 hasConceptScore W2073228346C114851261 @default.
• W2073228346 hasConceptScore W2073228346C126322002 @default.
• W2073228346 hasConceptScore W2073228346C133936738 @default.
• W2073228346 hasConceptScore W2073228346C154317977 @default.
• W2073228346 hasConceptScore W2073228346C202751555 @default.
• W2073228346 hasConceptScore W2073228346C2776694085 @default.
• W2073228346 hasConceptScore W2073228346C2778019345 @default.
• W2073228346 hasConceptScore W2073228346C2778707650 @default.
• W2073228346 hasConceptScore W2073228346C2780783641 @default.
• W2073228346 hasConceptScore W2073228346C2781303535 @default.
• W2073228346 hasConceptScore W2073228346C502942594 @default.
• W2073228346 hasConceptScore W2073228346C54355233 @default.
• W2073228346 hasConceptScore W2073228346C55493867 @default.
• W2073228346 hasConceptScore W2073228346C556039675 @default.
• W2073228346 hasConceptScore W2073228346C71924100 @default.
• W2073228346 hasConceptScore W2073228346C81885089 @default.
• W2073228346 hasConceptScore W2073228346C86803240 @default.
• W2073228346 hasConceptScore W2073228346C89423630 @default.
• W2073228346 hasConceptScore W2073228346C98274493 @default.
• W2073228346 hasLocation W20732283461 @default.
• W2073228346 hasLocation W20732283462 @default.
• W2073228346 hasOpenAccess W2073228346 @default.
• W2073228346 hasPrimaryLocation W20732283461 @default.
• W2073228346 hasRelatedWork W178323472 @default.
• W2073228346 hasRelatedWork W1982477267 @default.
• W2073228346 hasRelatedWork W2041509884 @default.
• W2073228346 hasRelatedWork W2045337788 @default.
• W2073228346 hasRelatedWork W2060293769 @default.
• W2073228346 hasRelatedWork W2068187946 @default.
• W2073228346 hasRelatedWork W2120053869 @default.
• W2073228346 hasRelatedWork W2317701824 @default.
• W2073228346 hasRelatedWork W2344730367 @default.
• W2073228346 hasRelatedWork W2349421491 @default.
• W2073228346 hasRelatedWork W2358810028 @default.
• W2073228346 hasRelatedWork W2365078093 @default.
• W2073228346 hasRelatedWork W2367334320 @default.
• W2073228346 hasRelatedWork W2384819786 @default.
• W2073228346 hasRelatedWork W2980599319 @default.

• next