FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073236573> ?p ?o ?g. }

• W2073236573 endingPage "718" @default.
• W2073236573 startingPage "706" @default.
• W2073236573 abstract "The long-term effects of brief but repetitive febrile seizures (FS) on memory have not been as thoroughly investigated as the impact of single and prolonged seizure in the developing brain. Using a heated-air FS paradigm, we subjected male rat pups to one, three, or nine episodes of brief FS on days 10 to 12 postpartum. Neither hippocampal neuronal damage nor apoptosis was noted within 72 hours after FS, nor was there significant hippocampal neuronal loss, aberrant mossy fiber sprouting, or altered seizure threshold to pentylenetetrazol in any FS group at adulthood. The adult rats subjected to nine episodes of early-life FS, however, showed long-term memory deficits as assessed by the Morris water maze. They also exhibited impaired intermediate and long-term memory but spared short-term memory in the inhibitory avoidance task. Three hours after inhibitory avoidance training, phosphorylation of cAMP response-element binding (CREB) protein in the hippocampus was significantly lower in nine-FS-group rats than in controls. Furthermore, rolipram administration, which activated the cAMP–CREB signaling pathway by inhibiting phosphodiesterase type IV, reversed the long-term memory deficits in nine-FS-group rats by enhancing hippocampal CREB phosphorylation. These results raise concerns about the long-term cognitive consequences of even brief frequently repetitive FS during early brain development. Ann Neurol 2003;54:706–718" @default.
• W2073236573 created "2016-06-24" @default.
• W2073236573 creator A5000799438 @default.
• W2073236573 creator A5024479180 @default.
• W2073236573 creator A5042672867 @default.
• W2073236573 creator A5049253275 @default.
• W2073236573 creator A5058815309 @default.
• W2073236573 creator A5062040842 @default.
• W2073236573 date "2003-11-26" @default.
• W2073236573 modified "2023-10-17" @default.
• W2073236573 title "Febrile seizures impair memory and cAMP response-element binding protein activation" @default.
• W2073236573 cites W1489716577 @default.
• W2073236573 cites W1494919617 @default.
• W2073236573 cites W1499000998 @default.
• W2073236573 cites W1542081124 @default.
• W2073236573 cites W1570032933 @default.
• W2073236573 cites W1946757792 @default.
• W2073236573 cites W1964156019 @default.
• W2073236573 cites W1968946845 @default.
• W2073236573 cites W1969480628 @default.
• W2073236573 cites W1976639286 @default.
• W2073236573 cites W1982316069 @default.
• W2073236573 cites W1984499529 @default.
• W2073236573 cites W1987864204 @default.
• W2073236573 cites W1989114376 @default.
• W2073236573 cites W1990486199 @default.
• W2073236573 cites W1995536650 @default.
• W2073236573 cites W1998448534 @default.
• W2073236573 cites W1999782689 @default.
• W2073236573 cites W2000584049 @default.
• W2073236573 cites W2002085774 @default.
• W2073236573 cites W2013632767 @default.
• W2073236573 cites W2014892312 @default.
• W2073236573 cites W2018986911 @default.
• W2073236573 cites W2021645572 @default.
• W2073236573 cites W2023796149 @default.
• W2073236573 cites W2029028573 @default.
• W2073236573 cites W2031079404 @default.
• W2073236573 cites W2040716985 @default.
• W2073236573 cites W2042339761 @default.
• W2073236573 cites W2050831289 @default.
• W2073236573 cites W2056487912 @default.
• W2073236573 cites W2063383783 @default.
• W2073236573 cites W2065620933 @default.
• W2073236573 cites W2068412840 @default.
• W2073236573 cites W2073883027 @default.
• W2073236573 cites W2074878857 @default.
• W2073236573 cites W2078848172 @default.
• W2073236573 cites W2079517399 @default.
• W2073236573 cites W2092959372 @default.
• W2073236573 cites W2094129223 @default.
• W2073236573 cites W2110948687 @default.
• W2073236573 cites W2130270377 @default.
• W2073236573 cites W2133083344 @default.
• W2073236573 cites W2135251933 @default.
• W2073236573 cites W2142664907 @default.
• W2073236573 cites W2151368438 @default.
• W2073236573 cites W2333449627 @default.
• W2073236573 doi "https://doi.org/10.1002/ana.10789" @default.
• W2073236573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14681880" @default.
• W2073236573 hasPublicationYear "2003" @default.
• W2073236573 type Work @default.
• W2073236573 sameAs 2073236573 @default.
• W2073236573 citedByCount "124" @default.
• W2073236573 countsByYear W20732365732012 @default.
• W2073236573 countsByYear W20732365732013 @default.
• W2073236573 countsByYear W20732365732014 @default.
• W2073236573 countsByYear W20732365732015 @default.
• W2073236573 countsByYear W20732365732017 @default.
• W2073236573 countsByYear W20732365732018 @default.
• W2073236573 countsByYear W20732365732019 @default.
• W2073236573 countsByYear W20732365732020 @default.
• W2073236573 countsByYear W20732365732021 @default.
• W2073236573 countsByYear W20732365732022 @default.
• W2073236573 countsByYear W20732365732023 @default.
• W2073236573 crossrefType "journal-article" @default.
• W2073236573 hasAuthorship W2073236573A5000799438 @default.
• W2073236573 hasAuthorship W2073236573A5024479180 @default.
• W2073236573 hasAuthorship W2073236573A5042672867 @default.
• W2073236573 hasAuthorship W2073236573A5049253275 @default.
• W2073236573 hasAuthorship W2073236573A5058815309 @default.
• W2073236573 hasAuthorship W2073236573A5062040842 @default.
• W2073236573 hasConcept C104317684 @default.
• W2073236573 hasConcept C126322002 @default.
• W2073236573 hasConcept C134018914 @default.
• W2073236573 hasConcept C148762608 @default.
• W2073236573 hasConcept C15744967 @default.
• W2073236573 hasConcept C1629964 @default.
• W2073236573 hasConcept C169760540 @default.
• W2073236573 hasConcept C169900460 @default.
• W2073236573 hasConcept C181199279 @default.
• W2073236573 hasConcept C185592680 @default.
• W2073236573 hasConcept C2775858608 @default.
• W2073236573 hasConcept C2776819090 @default.
• W2073236573 hasConcept C2776958096 @default.
• W2073236573 hasConcept C2778186239 @default.
• W2073236573 hasConcept C2781161787 @default.
• W2073236573 hasConcept C3018842126 @default.

• next