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• W2073238524 abstract "The previously discovered salicylhydrazide class of compounds displayed potent HIV-1 integrase (IN) inhibitory activity. The development of this class of compounds as antiretroviral agents was halted due to cytotoxicity in the nanomolar to sub-micromolar range. We identified a novel class of non-cytotoxic hydrazide IN inhibitors utilizing the minimally required salicylhydrazide substructure as a template in a small-molecule database search. The novel hydrazides displayed low micromolar IN inhibitory activity and are several hundred-fold less cytotoxic than previously disclosed salicylhydrazide IN inhibitors." @default.
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• W2073238524 date "2007-12-01" @default.
• W2073238524 modified "2023-10-14" @default.
• W2073238524 title "Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors" @default.
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• W2073238524 doi "https://doi.org/10.1016/j.bmcl.2007.09.102" @default.
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