FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073249623> ?p ?o ?g. }

• W2073249623 endingPage "1018" @default.
• W2073249623 startingPage "1007" @default.
• W2073249623 abstract "Frontotemporal lobar degeneration with τ pathology (FTLD-tau) is one of a group of neurodegenerative diseases that manifests with cognitive decline. Alzheimer (AD) and cerebrovascular lesions are commonly noted in the brains of most elderly individuals, begging the question as to whether (a) coexisting AD and vascular pathology or age contribute to the development of FTLD-tau disorders and vice versa and (b) FTLD-tau-like pathology can be found in non-diseased individuals. We studied brains of FTLD-tau cases exhibiting (a) argyrophilc grain disease (AGD), (b) progressive supranuclear palsy (PSP), (c) corticobasal degeneration (CBD), or (d) Pick's disease (PiD) for coexisting AD and vascular pathology for comparison with that of non-diseased individuals and AD patients. We confirmed that AGD lowered the threshold for AD pathology to cause dementia. Such an effect was not seen in PSP, CBD, or PiD. In PiD, white matter degeneration and demyelination was observed in the frontal and temporal lobes in association with small vessel disease (SVD)-related changes in white matter arteries. Age at death varied among the four types of FTLD-tau. PiD cases were youngest at death followed by CBD, PSP, and finally AGD. In 9.8% of non-diseased controls, we found grains, coiled bodies, and/or τ-positive astrocytes mimicking an AGD-like pattern. Moreover, the prevalence of FTLD-tau pathology in non-diseased individuals increased with age. In summary, this study demonstrates that age impacts of the diversity of neuropathological changes in FTLD-tau. The age-related coexistence of AD-related pathology is, thereby, associated with AGD but not with PSP, CBD, and PiD. Moreover, severe SVD and white matter demyelination is associated with PiD indicating a role of vascular copathology in this type of FTLD-tau. Finally, our finding that FTLD-tau-related pathological lesions occur in non-diseased individuals suggests that preclinical stages of FTLD-tau exist. As such, our results indicate that age, together with vascular and AD-related copathology, contributes to the morphological appearance of FTLD-tau." @default.
• W2073249623 created "2016-06-24" @default.
• W2073249623 creator A5021533014 @default.
• W2073249623 creator A5023861108 @default.
• W2073249623 creator A5036062855 @default.
• W2073249623 creator A5058254286 @default.
• W2073249623 creator A5063848159 @default.
• W2073249623 creator A5077963659 @default.
• W2073249623 creator A5080821885 @default.
• W2073249623 date "2015-01-04" @default.
• W2073249623 modified "2023-10-14" @default.
• W2073249623 title "Frontotemporal lobar degeneration FTLD-tau: preclinical lesions, vascular, and Alzheimer-related co-pathologies" @default.
• W2073249623 cites W10604852 @default.
• W2073249623 cites W1237501959 @default.
• W2073249623 cites W1603244154 @default.
• W2073249623 cites W1971032265 @default.
• W2073249623 cites W1978457897 @default.
• W2073249623 cites W1979060890 @default.
• W2073249623 cites W1979834756 @default.
• W2073249623 cites W1983611639 @default.
• W2073249623 cites W1990107252 @default.
• W2073249623 cites W1993023011 @default.
• W2073249623 cites W1993598577 @default.
• W2073249623 cites W1993609552 @default.
• W2073249623 cites W2001451770 @default.
• W2073249623 cites W2005223525 @default.
• W2073249623 cites W2017159332 @default.
• W2073249623 cites W2020206355 @default.
• W2073249623 cites W2020697171 @default.
• W2073249623 cites W2021753155 @default.
• W2073249623 cites W2038768096 @default.
• W2073249623 cites W2039220230 @default.
• W2073249623 cites W2041390299 @default.
• W2073249623 cites W2046113592 @default.
• W2073249623 cites W2052742260 @default.
• W2073249623 cites W2057643747 @default.
• W2073249623 cites W2067439875 @default.
• W2073249623 cites W2070446123 @default.
• W2073249623 cites W2071148852 @default.
• W2073249623 cites W2077305071 @default.
• W2073249623 cites W2081825327 @default.
• W2073249623 cites W2087529125 @default.
• W2073249623 cites W2093650784 @default.
• W2073249623 cites W2094512334 @default.
• W2073249623 cites W2106931873 @default.
• W2073249623 cites W2115310040 @default.
• W2073249623 cites W2120070267 @default.
• W2073249623 cites W2129497119 @default.
• W2073249623 cites W2131478918 @default.
• W2073249623 cites W2134980930 @default.
• W2073249623 cites W2143461767 @default.
• W2073249623 cites W2146729934 @default.
• W2073249623 cites W2154680505 @default.
• W2073249623 cites W2463189234 @default.
• W2073249623 cites W2752287204 @default.
• W2073249623 doi "https://doi.org/10.1007/s00702-014-1360-6" @default.
• W2073249623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6655426" @default.
• W2073249623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25556950" @default.
• W2073249623 hasPublicationYear "2015" @default.
• W2073249623 type Work @default.
• W2073249623 sameAs 2073249623 @default.
• W2073249623 citedByCount "46" @default.
• W2073249623 countsByYear W20732496232015 @default.
• W2073249623 countsByYear W20732496232016 @default.
• W2073249623 countsByYear W20732496232017 @default.
• W2073249623 countsByYear W20732496232018 @default.
• W2073249623 countsByYear W20732496232019 @default.
• W2073249623 countsByYear W20732496232020 @default.
• W2073249623 countsByYear W20732496232021 @default.
• W2073249623 countsByYear W20732496232022 @default.
• W2073249623 countsByYear W20732496232023 @default.
• W2073249623 crossrefType "journal-article" @default.
• W2073249623 hasAuthorship W2073249623A5021533014 @default.
• W2073249623 hasAuthorship W2073249623A5023861108 @default.
• W2073249623 hasAuthorship W2073249623A5036062855 @default.
• W2073249623 hasAuthorship W2073249623A5058254286 @default.
• W2073249623 hasAuthorship W2073249623A5063848159 @default.
• W2073249623 hasAuthorship W2073249623A5077963659 @default.
• W2073249623 hasAuthorship W2073249623A5080821885 @default.
• W2073249623 hasBestOaLocation W20732496232 @default.
• W2073249623 hasConcept C126838900 @default.
• W2073249623 hasConcept C142724271 @default.
• W2073249623 hasConcept C143409427 @default.
• W2073249623 hasConcept C15744967 @default.
• W2073249623 hasConcept C16568411 @default.
• W2073249623 hasConcept C169760540 @default.
• W2073249623 hasConcept C2776477761 @default.
• W2073249623 hasConcept C2776936178 @default.
• W2073249623 hasConcept C2776939681 @default.
• W2073249623 hasConcept C2777427615 @default.
• W2073249623 hasConcept C2777952318 @default.
• W2073249623 hasConcept C2778641062 @default.
• W2073249623 hasConcept C2779134260 @default.
• W2073249623 hasConcept C2779483572 @default.
• W2073249623 hasConcept C2781192897 @default.
• W2073249623 hasConcept C3017833866 @default.
• W2073249623 hasConcept C502032728 @default.
• W2073249623 hasConcept C71924100 @default.

• next