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• W2073251119 abstract "AKT is a serine/threonine kinase activated downstream of integrin, which is a receptor for various pro-proliferation and bioactive substances as well as the extracellular matrix receptor. The activation of AKT often contributes to tumorigenesis and plays a role in regulating cell motility, which is critical for local invasion and metastasis. In recent years, it has also drawn attention as a target of new molecular-targeted agents. When analyzing the role of AKT in cancer cells, it is important to consider the microenvironment and variations of cancers. In this review, a basic overview of the role of AKT in normal and malignant tissues is provided, along with an in-depth discussion of its role in gastric cancer and its potential as a target for therapy." @default.
• W2073251119 created "2016-06-24" @default.
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• W2073251119 date "2014-09-26" @default.
• W2073251119 modified "2023-10-12" @default.
• W2073251119 title "Significance of AKT in gastric cancer (Review)" @default.
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• W2073251119 doi "https://doi.org/10.3892/ijo.2014.2678" @default.
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