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• W2073252604 endingPage "436" @default.
• W2073252604 startingPage "431" @default.
• W2073252604 abstract "Abstract Kinins are potent vasoactive peptides generated in blood and tissues by the kallikrein serine proteases. Two distinct kinin receptors have been described, one constitutive (subtype B 2 ) and one inducible (subtype B 1 ), and many physiological functions have been attributed to these receptors, including glucose homeostasis and control of vascular permeability. In this study we show that mice lacking the kinin B 1 receptor (B 1 -/- mice) have lower fasting plasma glucose concentrations but exhibit higher glycemia after feeding when compared to wild-type mice. B 1 -/- mice also present pancreas abnormalities, characterized by fewer pancreatic islets and lower insulin content, which leads to hypoinsulinemia and reduced insulin release after a glucose load. Nevertheless, an insulin tolerance test indicated higher sensitivity in B 1 -/- mice. In line with this phenotype, pancreatic vascular permeability was shown to be reduced in B 1 receptor-ablated mice. The B 1 agonist desArg 9 bradykinin injected intravenously can induce the release of insulin into serum, and this effect was not observed in the B 1 -/- mice or in isolated islets. Our data demonstrate the importance of the kinin B 1 receptor in the control of pancreatic vascular homeostasis and insulin release, highlighting a new role for this receptor in the pathogenesis of diabetes and related diseases." @default.
• W2073252604 created "2016-06-24" @default.
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• W2073252604 date "2006-04-01" @default.
• W2073252604 modified "2023-10-16" @default.
• W2073252604 title "Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function" @default.
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• W2073252604 doi "https://doi.org/10.1515/bc.2006.057" @default.
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