FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073254246> ?p ?o ?g. }

• W2073254246 endingPage "19" @default.
• W2073254246 startingPage "11" @default.
• W2073254246 abstract "Despite great interspecies differences in adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) sensitivity, the toxic potency of TCDD is similar across species in fetal mortality. Han/Wistar (Kuopio; H/W) rats are exceptionally resistant to acute toxicity of TCDD, but show sensitivity to embryotoxicity and teratogenicity. The resistance of adult H/W rats to acute TCDD toxicity is based on a point mutation in the transactivation domain of the aryl hydrocarbon receptor (AHR) and to an unknown gene B. This study investigated the time course of postnatal development of resistance to TCDD and the significance of genotypic variation in resistance development. H/W, line A (a new line with the H/W-type mutated AHR), and line B rats (a line with normal AHR but moderately resistant because of gene B) were exposed to a single dose of TCDD 2-56 days after birth. H/W and line A rats received 1000 microg/kg; male and female B rats received 200 and 100 microg/kg, respectively. Survival was monitored for 42 days. Interestingly, although TCDD ceased growth and weight gain in all TCDD groups, the younger dosed animals did not seem to reach the body weight of the older dosed animals even in 100 days. The survival results after 42 days showed that line A rats are fairly resistant to TCDD immediately after birth, and their full TCDD resistance develops during the first week of life. The moderate resistance of line B rats develops approximately at the time of weaning. This difference in the time course of resistance development suggests that there are basic differences in pathways mediating resistance in lines A and B rats." @default.
• W2073254246 created "2016-06-24" @default.
• W2073254246 creator A5011985392 @default.
• W2073254246 creator A5023220284 @default.
• W2073254246 creator A5030829295 @default.
• W2073254246 creator A5049444731 @default.
• W2073254246 creator A5066426429 @default.
• W2073254246 creator A5075856758 @default.
• W2073254246 date "2004-04-01" @default.
• W2073254246 modified "2023-10-15" @default.
• W2073254246 title "Postnatal development of resistance to short-term high-dose toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in TCDD-resistant and -semiresistant rats" @default.
• W2073254246 cites W1970869028 @default.
• W2073254246 cites W1982866393 @default.
• W2073254246 cites W1987198577 @default.
• W2073254246 cites W1994057267 @default.
• W2073254246 cites W2017549286 @default.
• W2073254246 cites W2026884057 @default.
• W2073254246 cites W2037830178 @default.
• W2073254246 cites W2039608699 @default.
• W2073254246 cites W2046271197 @default.
• W2073254246 cites W2052839050 @default.
• W2073254246 cites W2053728651 @default.
• W2073254246 cites W2058260649 @default.
• W2073254246 cites W2059565720 @default.
• W2073254246 cites W2068055802 @default.
• W2073254246 cites W2069306306 @default.
• W2073254246 cites W2079005276 @default.
• W2073254246 cites W2082517129 @default.
• W2073254246 cites W2094234986 @default.
• W2073254246 cites W2099881016 @default.
• W2073254246 cites W2136306660 @default.
• W2073254246 cites W2140257462 @default.
• W2073254246 cites W2160811937 @default.
• W2073254246 cites W2171196252 @default.
• W2073254246 cites W3215553012 @default.
• W2073254246 doi "https://doi.org/10.1016/j.taap.2003.11.025" @default.
• W2073254246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15050403" @default.
• W2073254246 hasPublicationYear "2004" @default.
• W2073254246 type Work @default.
• W2073254246 sameAs 2073254246 @default.
• W2073254246 citedByCount "7" @default.
• W2073254246 countsByYear W20732542462014 @default.
• W2073254246 countsByYear W20732542462021 @default.
• W2073254246 crossrefType "journal-article" @default.
• W2073254246 hasAuthorship W2073254246A5011985392 @default.
• W2073254246 hasAuthorship W2073254246A5023220284 @default.
• W2073254246 hasAuthorship W2073254246A5030829295 @default.
• W2073254246 hasAuthorship W2073254246A5049444731 @default.
• W2073254246 hasAuthorship W2073254246A5066426429 @default.
• W2073254246 hasAuthorship W2073254246A5075856758 @default.
• W2073254246 hasConcept C104317684 @default.
• W2073254246 hasConcept C126322002 @default.
• W2073254246 hasConcept C134018914 @default.
• W2073254246 hasConcept C172680121 @default.
• W2073254246 hasConcept C2779234561 @default.
• W2073254246 hasConcept C2780655333 @default.
• W2073254246 hasConcept C2909724048 @default.
• W2073254246 hasConcept C29730261 @default.
• W2073254246 hasConcept C33594762 @default.
• W2073254246 hasConcept C54355233 @default.
• W2073254246 hasConcept C55493867 @default.
• W2073254246 hasConcept C71924100 @default.
• W2073254246 hasConcept C79410662 @default.
• W2073254246 hasConcept C86339819 @default.
• W2073254246 hasConcept C86803240 @default.
• W2073254246 hasConceptScore W2073254246C104317684 @default.
• W2073254246 hasConceptScore W2073254246C126322002 @default.
• W2073254246 hasConceptScore W2073254246C134018914 @default.
• W2073254246 hasConceptScore W2073254246C172680121 @default.
• W2073254246 hasConceptScore W2073254246C2779234561 @default.
• W2073254246 hasConceptScore W2073254246C2780655333 @default.
• W2073254246 hasConceptScore W2073254246C2909724048 @default.
• W2073254246 hasConceptScore W2073254246C29730261 @default.
• W2073254246 hasConceptScore W2073254246C33594762 @default.
• W2073254246 hasConceptScore W2073254246C54355233 @default.
• W2073254246 hasConceptScore W2073254246C55493867 @default.
• W2073254246 hasConceptScore W2073254246C71924100 @default.
• W2073254246 hasConceptScore W2073254246C79410662 @default.
• W2073254246 hasConceptScore W2073254246C86339819 @default.
• W2073254246 hasConceptScore W2073254246C86803240 @default.
• W2073254246 hasIssue "1" @default.
• W2073254246 hasLocation W20732542461 @default.
• W2073254246 hasLocation W20732542462 @default.
• W2073254246 hasOpenAccess W2073254246 @default.
• W2073254246 hasPrimaryLocation W20732542461 @default.
• W2073254246 hasRelatedWork W1992086828 @default.
• W2073254246 hasRelatedWork W2021207106 @default.
• W2073254246 hasRelatedWork W2058307422 @default.
• W2073254246 hasRelatedWork W2091983127 @default.
• W2073254246 hasRelatedWork W2106828929 @default.
• W2073254246 hasRelatedWork W2141167633 @default.
• W2073254246 hasRelatedWork W2382593370 @default.
• W2073254246 hasRelatedWork W244423452 @default.
• W2073254246 hasRelatedWork W2463801086 @default.
• W2073254246 hasRelatedWork W2804543904 @default.
• W2073254246 hasVolume "196" @default.
• W2073254246 isParatext "false" @default.
• W2073254246 isRetracted "false" @default.

• next