FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073254297> ?p ?o ?g. }

• W2073254297 endingPage "4425" @default.
• W2073254297 startingPage "4420" @default.
• W2073254297 abstract "A series of N-heteroaryl hydrazones derived from aryl N-heteroaryl or bis-N-heteroaryl methanones was prepared in search for potential novel antitumor agents. The stereochemistry of these compounds was established by means of NMR spectroscopy. Antiproliferative activity was determined in a panel of human tumor cell lines (CCRF-CEM, Burkitt's lymphoma, HeLa, ZR-75-1, HT-29, and MEXF 276L) in vitro. Generally, the new compounds were found to be more potent (IC50 = 0.011-0.436 microM) than the ribonucleotide reductase inhibitor hydroxyurea (IC50 = 140 microM). Most of the compounds exhibited the highest activity against Burkitt's lymphoma with an IC50 of 0.011-0.035 microM. [14C]Cytidine incorporation into DNA was quantitated for selected hydrazones (Z-A, E-1, Z-3, Z-4, E-5, Z-5, E-13, E-18, Z-19, Z-24, and E-26) as a measure of the inhibition of ribonucleotide reductase in Burkitt's lymphoma cells. The E-configurated compounds were found to inhibit [14C]cytidine incorporation to a greater extent (IC50 = 0.67-5.05 microM) than the Z-isomers (IC50 = 7.20 to > 10 microM). Principal component analysis of the IC50 values obtained for inhibition of cell proliferation revealed that the cell lines tested can be grouped into three main families showing different sensitivities toward the compounds in our series [(i) CCRF-CEM, Burkitt's lymphoma, and Hela; (ii) HT-29; and (iii) MEXF 276 L]." @default.
• W2073254297 created "2016-06-24" @default.
• W2073254297 creator A5000795211 @default.
• W2073254297 creator A5010598506 @default.
• W2073254297 creator A5018953645 @default.
• W2073254297 creator A5022361290 @default.
• W2073254297 creator A5038868084 @default.
• W2073254297 creator A5069424443 @default.
• W2073254297 creator A5074878764 @default.
• W2073254297 date "1997-12-01" @default.
• W2073254297 modified "2023-09-28" @default.
• W2073254297 title "Azinyl and Diazinyl Hydrazones Derived from Aryl <i>N</i>-Heteroaryl Ketones: Synthesis and Antiproliferative Activity^," @default.
• W2073254297 cites W1577909961 @default.
• W2073254297 cites W1982856093 @default.
• W2073254297 cites W1993436180 @default.
• W2073254297 cites W2004149058 @default.
• W2073254297 cites W2048512883 @default.
• W2073254297 cites W2063008498 @default.
• W2073254297 cites W2063060349 @default.
• W2073254297 cites W2072168907 @default.
• W2073254297 cites W2084946151 @default.
• W2073254297 cites W2109689528 @default.
• W2073254297 cites W2323792825 @default.
• W2073254297 cites W2950113660 @default.
• W2073254297 doi "https://doi.org/10.1021/jm970255w" @default.
• W2073254297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9435912" @default.
• W2073254297 hasPublicationYear "1997" @default.
• W2073254297 type Work @default.
• W2073254297 sameAs 2073254297 @default.
• W2073254297 citedByCount "44" @default.
• W2073254297 countsByYear W20732542972012 @default.
• W2073254297 countsByYear W20732542972013 @default.
• W2073254297 countsByYear W20732542972014 @default.
• W2073254297 countsByYear W20732542972015 @default.
• W2073254297 countsByYear W20732542972016 @default.
• W2073254297 countsByYear W20732542972017 @default.
• W2073254297 countsByYear W20732542972018 @default.
• W2073254297 countsByYear W20732542972019 @default.
• W2073254297 countsByYear W20732542972020 @default.
• W2073254297 countsByYear W20732542972021 @default.
• W2073254297 countsByYear W20732542972022 @default.
• W2073254297 crossrefType "journal-article" @default.
• W2073254297 hasAuthorship W2073254297A5000795211 @default.
• W2073254297 hasAuthorship W2073254297A5010598506 @default.
• W2073254297 hasAuthorship W2073254297A5018953645 @default.
• W2073254297 hasAuthorship W2073254297A5022361290 @default.
• W2073254297 hasAuthorship W2073254297A5038868084 @default.
• W2073254297 hasAuthorship W2073254297A5069424443 @default.
• W2073254297 hasAuthorship W2073254297A5074878764 @default.
• W2073254297 hasConcept C104292427 @default.
• W2073254297 hasConcept C104317684 @default.
• W2073254297 hasConcept C181199279 @default.
• W2073254297 hasConcept C185592680 @default.
• W2073254297 hasConcept C202751555 @default.
• W2073254297 hasConcept C2777366897 @default.
• W2073254297 hasConcept C2777752497 @default.
• W2073254297 hasConcept C2781184954 @default.
• W2073254297 hasConcept C4710235 @default.
• W2073254297 hasConcept C512185932 @default.
• W2073254297 hasConcept C54355233 @default.
• W2073254297 hasConcept C55493867 @default.
• W2073254297 hasConcept C71240020 @default.
• W2073254297 hasConcept C81885089 @default.
• W2073254297 hasConcept C86803240 @default.
• W2073254297 hasConcept C98892162 @default.
• W2073254297 hasConceptScore W2073254297C104292427 @default.
• W2073254297 hasConceptScore W2073254297C104317684 @default.
• W2073254297 hasConceptScore W2073254297C181199279 @default.
• W2073254297 hasConceptScore W2073254297C185592680 @default.
• W2073254297 hasConceptScore W2073254297C202751555 @default.
• W2073254297 hasConceptScore W2073254297C2777366897 @default.
• W2073254297 hasConceptScore W2073254297C2777752497 @default.
• W2073254297 hasConceptScore W2073254297C2781184954 @default.
• W2073254297 hasConceptScore W2073254297C4710235 @default.
• W2073254297 hasConceptScore W2073254297C512185932 @default.
• W2073254297 hasConceptScore W2073254297C54355233 @default.
• W2073254297 hasConceptScore W2073254297C55493867 @default.
• W2073254297 hasConceptScore W2073254297C71240020 @default.
• W2073254297 hasConceptScore W2073254297C81885089 @default.
• W2073254297 hasConceptScore W2073254297C86803240 @default.
• W2073254297 hasConceptScore W2073254297C98892162 @default.
• W2073254297 hasIssue "26" @default.
• W2073254297 hasLocation W20732542971 @default.
• W2073254297 hasLocation W20732542972 @default.
• W2073254297 hasOpenAccess W2073254297 @default.
• W2073254297 hasPrimaryLocation W20732542971 @default.
• W2073254297 hasRelatedWork W152219614 @default.
• W2073254297 hasRelatedWork W1535189264 @default.
• W2073254297 hasRelatedWork W1991737003 @default.
• W2073254297 hasRelatedWork W1997642149 @default.
• W2073254297 hasRelatedWork W2027065989 @default.
• W2073254297 hasRelatedWork W2055236777 @default.
• W2073254297 hasRelatedWork W2073254297 @default.
• W2073254297 hasRelatedWork W21891353 @default.
• W2073254297 hasRelatedWork W2389741697 @default.
• W2073254297 hasRelatedWork W2427319065 @default.
• W2073254297 hasVolume "40" @default.
• W2073254297 isParatext "false" @default.

• next