FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073255047> ?p ?o ?g. }

• W2073255047 endingPage "1039" @default.
• W2073255047 startingPage "1034" @default.
• W2073255047 abstract "Background: We report the induction of gremlin, a bone morphogenetic protein antagonist, in cultured human mesangial cells exposed to high glucose and transforming growth factor β (TGF-β) levels in vitro and kidneys from diabetic rats in vivo. Methods: Gremlin expression was assessed in human diabetic nephropathy by means of in situ hybridization, immunohistochemistry, and real-time polymerase chain reaction and correlated with clinical and pathological indices of disease. Results: Gremlin was not expressed in normal human adult kidneys. Conversely, abundant gremlin expression was observed in human diabetic nephropathy. Although some gremlin expression was observed in occasional glomeruli, gremlin expression was most prominent in areas of tubulointerstitial fibrosis, where it colocalized with TGF-β expression. Gremlin messenger RNA levels correlated directly with renal dysfunction, determined by means of serum creatinine level, but not with proteinuria level. There was a strong correlation between gremlin expression and tubulointerstitial fibrosis score. Conclusion: In aggregate, these results indicate that the developmental gene gremlin reemerges in the context of tubulointerstitial fibrosis in diabetic nephropathy and suggests a role for TFG-β as an inducer of gremlin expression in this context. Background: We report the induction of gremlin, a bone morphogenetic protein antagonist, in cultured human mesangial cells exposed to high glucose and transforming growth factor β (TGF-β) levels in vitro and kidneys from diabetic rats in vivo. Methods: Gremlin expression was assessed in human diabetic nephropathy by means of in situ hybridization, immunohistochemistry, and real-time polymerase chain reaction and correlated with clinical and pathological indices of disease. Results: Gremlin was not expressed in normal human adult kidneys. Conversely, abundant gremlin expression was observed in human diabetic nephropathy. Although some gremlin expression was observed in occasional glomeruli, gremlin expression was most prominent in areas of tubulointerstitial fibrosis, where it colocalized with TGF-β expression. Gremlin messenger RNA levels correlated directly with renal dysfunction, determined by means of serum creatinine level, but not with proteinuria level. There was a strong correlation between gremlin expression and tubulointerstitial fibrosis score. Conclusion: In aggregate, these results indicate that the developmental gene gremlin reemerges in the context of tubulointerstitial fibrosis in diabetic nephropathy and suggests a role for TFG-β as an inducer of gremlin expression in this context." @default.
• W2073255047 created "2016-06-24" @default.
• W2073255047 creator A5003754642 @default.
• W2073255047 creator A5012999223 @default.
• W2073255047 creator A5013727618 @default.
• W2073255047 creator A5036440403 @default.
• W2073255047 creator A5045389285 @default.
• W2073255047 creator A5046173104 @default.
• W2073255047 creator A5048143074 @default.
• W2073255047 creator A5049852436 @default.
• W2073255047 creator A5051933177 @default.
• W2073255047 creator A5051959855 @default.
• W2073255047 creator A5059217303 @default.
• W2073255047 creator A5063207633 @default.
• W2073255047 creator A5073141203 @default.
• W2073255047 creator A5090729869 @default.
• W2073255047 date "2005-06-01" @default.
• W2073255047 modified "2023-10-16" @default.
• W2073255047 title "Expression of Gremlin, a Bone Morphogenetic Protein Antagonist, in Human Diabetic Nephropathy" @default.
• W2073255047 cites W1977303408 @default.
• W2073255047 cites W1983752167 @default.
• W2073255047 cites W1985432260 @default.
• W2073255047 cites W1995791071 @default.
• W2073255047 cites W1998539941 @default.
• W2073255047 cites W1998880332 @default.
• W2073255047 cites W2007375364 @default.
• W2073255047 cites W2016271685 @default.
• W2073255047 cites W2033771065 @default.
• W2073255047 cites W2044384686 @default.
• W2073255047 cites W2056437480 @default.
• W2073255047 cites W2060089472 @default.
• W2073255047 cites W2076087769 @default.
• W2073255047 cites W2098159639 @default.
• W2073255047 cites W2104360806 @default.
• W2073255047 cites W2114245705 @default.
• W2073255047 cites W2120045068 @default.
• W2073255047 cites W2125486836 @default.
• W2073255047 cites W2145356697 @default.
• W2073255047 cites W2154316494 @default.
• W2073255047 cites W2161736514 @default.
• W2073255047 cites W2162396660 @default.
• W2073255047 cites W2168456732 @default.
• W2073255047 doi "https://doi.org/10.1053/j.ajkd.2005.03.014" @default.
• W2073255047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15957132" @default.
• W2073255047 hasPublicationYear "2005" @default.
• W2073255047 type Work @default.
• W2073255047 sameAs 2073255047 @default.
• W2073255047 citedByCount "124" @default.
• W2073255047 countsByYear W20732550472012 @default.
• W2073255047 countsByYear W20732550472013 @default.
• W2073255047 countsByYear W20732550472014 @default.
• W2073255047 countsByYear W20732550472015 @default.
• W2073255047 countsByYear W20732550472016 @default.
• W2073255047 countsByYear W20732550472017 @default.
• W2073255047 countsByYear W20732550472018 @default.
• W2073255047 countsByYear W20732550472019 @default.
• W2073255047 countsByYear W20732550472020 @default.
• W2073255047 countsByYear W20732550472021 @default.
• W2073255047 countsByYear W20732550472022 @default.
• W2073255047 countsByYear W20732550472023 @default.
• W2073255047 crossrefType "journal-article" @default.
• W2073255047 hasAuthorship W2073255047A5003754642 @default.
• W2073255047 hasAuthorship W2073255047A5012999223 @default.
• W2073255047 hasAuthorship W2073255047A5013727618 @default.
• W2073255047 hasAuthorship W2073255047A5036440403 @default.
• W2073255047 hasAuthorship W2073255047A5045389285 @default.
• W2073255047 hasAuthorship W2073255047A5046173104 @default.
• W2073255047 hasAuthorship W2073255047A5048143074 @default.
• W2073255047 hasAuthorship W2073255047A5049852436 @default.
• W2073255047 hasAuthorship W2073255047A5051933177 @default.
• W2073255047 hasAuthorship W2073255047A5051959855 @default.
• W2073255047 hasAuthorship W2073255047A5059217303 @default.
• W2073255047 hasAuthorship W2073255047A5063207633 @default.
• W2073255047 hasAuthorship W2073255047A5073141203 @default.
• W2073255047 hasAuthorship W2073255047A5090729869 @default.
• W2073255047 hasConcept C104317684 @default.
• W2073255047 hasConcept C125349252 @default.
• W2073255047 hasConcept C126322002 @default.
• W2073255047 hasConcept C134018914 @default.
• W2073255047 hasConcept C2779922275 @default.
• W2073255047 hasConcept C2781184683 @default.
• W2073255047 hasConcept C31507581 @default.
• W2073255047 hasConcept C55493867 @default.
• W2073255047 hasConcept C555293320 @default.
• W2073255047 hasConcept C71924100 @default.
• W2073255047 hasConcept C86803240 @default.
• W2073255047 hasConceptScore W2073255047C104317684 @default.
• W2073255047 hasConceptScore W2073255047C125349252 @default.
• W2073255047 hasConceptScore W2073255047C126322002 @default.
• W2073255047 hasConceptScore W2073255047C134018914 @default.
• W2073255047 hasConceptScore W2073255047C2779922275 @default.
• W2073255047 hasConceptScore W2073255047C2781184683 @default.
• W2073255047 hasConceptScore W2073255047C31507581 @default.
• W2073255047 hasConceptScore W2073255047C55493867 @default.
• W2073255047 hasConceptScore W2073255047C555293320 @default.
• W2073255047 hasConceptScore W2073255047C71924100 @default.
• W2073255047 hasConceptScore W2073255047C86803240 @default.
• W2073255047 hasIssue "6" @default.

• next