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• W2073256585 endingPage "4029" @default.
• W2073256585 startingPage "4025" @default.
• W2073256585 abstract "Technetium-99m labeling of antibodies has been suboptimal because of low affinity adventitious binding, nonspecific labeling, and loss of immunoreactivity. The diamide dithiolate ligand system (N2S2) forms highly stable, well-defined tetradentate complexes with Tc(V). Antibodies and their fragments have been labeled by conjugation of preformed 99mTc-4,5-bis(thioacetamido)pentanoate active ester to protein amine groups to give a chemically known 99mTc-N2S2 complex covalently linked to antibody. Evaluations of the 99mTc-N2S2-bound antibodies and their fragments have shown high stability and retained immunoreactivity." @default.
• W2073256585 created "2016-06-24" @default.
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• W2073256585 date "1988-06-01" @default.
• W2073256585 modified "2023-10-14" @default.
• W2073256585 title "Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent." @default.
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• W2073256585 doi "https://doi.org/10.1073/pnas.85.11.4025" @default.
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