FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073258230> ?p ?o ?g. }

• W2073258230 endingPage "16" @default.
• W2073258230 startingPage "15" @default.
• W2073258230 abstract "Spike–wave discharges (SWDs) are thalamocortical oscillations that are often considered to be the EEG correlate of absence seizures. Genetic absence epilepsy rats of Strasbourg (GAERS) and Wistar Albino Glaxo rats from Rijswijk (WAG/Rij) exhibit SWDs and are considered to be genetic animal models of absence epilepsy. However, it has been reported that other rat strains have SWDs, suggesting that SWDs may vary in their prevalence, but all rats have a predisposition for them. This is important because many of these rat strains are used to study temporal lobe epilepsy (TLE), where it is assumed that there is no seizure-like activity in controls. In the course of other studies using the Sprague–Dawley rat, a common rat strain for animal models of TLE, we found that approximately 19% of 2- to 3-month-old naive female Sprague–Dawley rats exhibited SWDs spontaneously during periods of behavioral arrest, which continued for months. Males exhibited SWDs only after 3 months of age, consistent with previous reports (Buzsáki et al., 1990). Housing in atypical lighting during early life appeared to facilitate the incidence of SWDs.Spike–wave discharges were often accompanied by behaviors similar to stage 1–2 limbic seizures. Therefore, additional analyses were made to address the similarity. We observed that the frequency of SWDs was similar to that of hippocampal theta rhythm during exploration for a given animal, typically 7–8 Hz. Therefore, activity in the frequency of theta rhythm that occurs during frozen behavior may not reflect seizures necessarily. Hippocampal recordings exhibited high frequency oscillations (> 250 Hz) during SWDs, suggesting that neuronal activity in the hippocampus occurs during SWDs, i.e., it is not a passive structure. The data also suggest that high frequency oscillations, if rhythmic, may reflect SWDs. We also confirmed that SWDs were present in a common animal model of TLE, the pilocarpine model, using female Sprague–Dawley rats. Therefore, damage and associated changes to thalamic, hippocampal, and cortical neurons do not prevent SWDs, at least in this animal model. The results suggest that it is possible that SWDs occur in rodent models of TLE and that investigators mistakenly assume that they are stage 1–2 limbic seizures. We discuss the implications of the results and ways to avoid the potential problems associated with SWDs in animal models of TLE." @default.
• W2073258230 created "2016-06-24" @default.
• W2073258230 creator A5020143047 @default.
• W2073258230 creator A5077864982 @default.
• W2073258230 creator A5084589380 @default.
• W2073258230 date "2014-09-01" @default.
• W2073258230 modified "2023-10-07" @default.
• W2073258230 title "Fetal skeletal imaging with micro-CT" @default.
• W2073258230 doi "https://doi.org/10.1016/j.reprotox.2014.07.011" @default.
• W2073258230 hasPublicationYear "2014" @default.
• W2073258230 type Work @default.
• W2073258230 sameAs 2073258230 @default.
• W2073258230 citedByCount "0" @default.
• W2073258230 crossrefType "journal-article" @default.
• W2073258230 hasAuthorship W2073258230A5020143047 @default.
• W2073258230 hasAuthorship W2073258230A5077864982 @default.
• W2073258230 hasAuthorship W2073258230A5084589380 @default.
• W2073258230 hasConcept C118552586 @default.
• W2073258230 hasConcept C126322002 @default.
• W2073258230 hasConcept C135343436 @default.
• W2073258230 hasConcept C148762608 @default.
• W2073258230 hasConcept C15744967 @default.
• W2073258230 hasConcept C169760540 @default.
• W2073258230 hasConcept C2778117688 @default.
• W2073258230 hasConcept C2778186239 @default.
• W2073258230 hasConcept C2779134260 @default.
• W2073258230 hasConcept C2781099131 @default.
• W2073258230 hasConcept C2781161787 @default.
• W2073258230 hasConcept C50965678 @default.
• W2073258230 hasConcept C522805319 @default.
• W2073258230 hasConcept C67636389 @default.
• W2073258230 hasConcept C71924100 @default.
• W2073258230 hasConcept C86803240 @default.
• W2073258230 hasConceptScore W2073258230C118552586 @default.
• W2073258230 hasConceptScore W2073258230C126322002 @default.
• W2073258230 hasConceptScore W2073258230C135343436 @default.
• W2073258230 hasConceptScore W2073258230C148762608 @default.
• W2073258230 hasConceptScore W2073258230C15744967 @default.
• W2073258230 hasConceptScore W2073258230C169760540 @default.
• W2073258230 hasConceptScore W2073258230C2778117688 @default.
• W2073258230 hasConceptScore W2073258230C2778186239 @default.
• W2073258230 hasConceptScore W2073258230C2779134260 @default.
• W2073258230 hasConceptScore W2073258230C2781099131 @default.
• W2073258230 hasConceptScore W2073258230C2781161787 @default.
• W2073258230 hasConceptScore W2073258230C50965678 @default.
• W2073258230 hasConceptScore W2073258230C522805319 @default.
• W2073258230 hasConceptScore W2073258230C67636389 @default.
• W2073258230 hasConceptScore W2073258230C71924100 @default.
• W2073258230 hasConceptScore W2073258230C86803240 @default.
• W2073258230 hasLocation W20732582301 @default.
• W2073258230 hasOpenAccess W2073258230 @default.
• W2073258230 hasPrimaryLocation W20732582301 @default.
• W2073258230 hasRelatedWork W1970180377 @default.
• W2073258230 hasRelatedWork W2008315268 @default.
• W2073258230 hasRelatedWork W2033768432 @default.
• W2073258230 hasRelatedWork W2102101945 @default.
• W2073258230 hasRelatedWork W2114324037 @default.
• W2073258230 hasRelatedWork W2403348907 @default.
• W2073258230 hasRelatedWork W2963706669 @default.
• W2073258230 hasRelatedWork W2989716236 @default.
• W2073258230 hasRelatedWork W4245162863 @default.
• W2073258230 hasRelatedWork W4304806825 @default.
• W2073258230 hasVolume "48" @default.
• W2073258230 isParatext "false" @default.
• W2073258230 isRetracted "false" @default.
• W2073258230 magId "2073258230" @default.
• W2073258230 workType "article" @default.