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• W2073266404 abstract "OBJECTIVE: To determine if endometrial thickness, follicular recruitment, follicular phase length, and pregnancy/live birth rates are affected by CC dose or initiation day.DESIGN: Retrospective study. Setting: Infertility unit at an academic hospital.MATERIALS AND METHODS: Data on 2669 ovulation induction/IUI cycles from 780 women was collected. Of those, Clomid was used for 636 cycles among 296 women. Outcome measure: clinical pregnancy and spontaneous abortion rates, day of hCG administration, endometrial thickness, number of pre-ovulatory follicles (dominant: ≥15mm and medium size 13-15mm).RESULTS: In a linear mixed effects model adjusting for age, BMI and day 3 FSH level, a CC dose of 100 mg was associated with an earlier hCG trigger by 0.6 days (95% confidence interval [CI] -1.0 to -0.2 days; p=0.008) compared to a 50 mg dose, while a 150 mg dose was associated with a later hCG trigger (fixed effects estimate = 3.4 day, 95% CI 1.6 to 5.3 days; p=0.0004). Start day of CC treatment was also predictive of day of hCG trigger, where start day 3 and start day 5 were associated with delays of 0.4 (95%CI -0.1 to 0.9) and 1.4 (0.9, 2.0) days in hCG trigger, respectively (p for trend <0.0001). There was a suggestive decline in maximum endometrial thickness among 100 mg dose cycles compared to 50 mg (p=0.07). No significant associations were observed between CC dose or CC start day and the number of follicles that were 13-15 mm, number of follicles ≥15 mm, or pregnancy rate. In a discrete survival analysis, cycles utilizing a 150 mg dose had a 5-fold increase in the odds of a successful live birth compared to 50 mg (odds ratio = 5.1, 95%CI 1.2 to 22.1; p=0.03). However, the analyses involving 150 mg dose were accompanied by wide confidence intervals due to the small number of cycles using this dosage (n=13), which may limit our interpretation of findings.CONCLUSIONS: Initiation of CC on day 2 resulted in a shorter stimulation phase. Day 2 or day 3 start did not increase the number of recruited follicles. There was a suggested decrease in endometrial thickness with higher doses of CC, regardless of start date. A higher dose of CC (150 mg) was associated with a higher live birth rate. OBJECTIVE: To determine if endometrial thickness, follicular recruitment, follicular phase length, and pregnancy/live birth rates are affected by CC dose or initiation day. DESIGN: Retrospective study. Setting: Infertility unit at an academic hospital. MATERIALS AND METHODS: Data on 2669 ovulation induction/IUI cycles from 780 women was collected. Of those, Clomid was used for 636 cycles among 296 women. Outcome measure: clinical pregnancy and spontaneous abortion rates, day of hCG administration, endometrial thickness, number of pre-ovulatory follicles (dominant: ≥15mm and medium size 13-15mm). RESULTS: In a linear mixed effects model adjusting for age, BMI and day 3 FSH level, a CC dose of 100 mg was associated with an earlier hCG trigger by 0.6 days (95% confidence interval [CI] -1.0 to -0.2 days; p=0.008) compared to a 50 mg dose, while a 150 mg dose was associated with a later hCG trigger (fixed effects estimate = 3.4 day, 95% CI 1.6 to 5.3 days; p=0.0004). Start day of CC treatment was also predictive of day of hCG trigger, where start day 3 and start day 5 were associated with delays of 0.4 (95%CI -0.1 to 0.9) and 1.4 (0.9, 2.0) days in hCG trigger, respectively (p for trend <0.0001). There was a suggestive decline in maximum endometrial thickness among 100 mg dose cycles compared to 50 mg (p=0.07). No significant associations were observed between CC dose or CC start day and the number of follicles that were 13-15 mm, number of follicles ≥15 mm, or pregnancy rate. In a discrete survival analysis, cycles utilizing a 150 mg dose had a 5-fold increase in the odds of a successful live birth compared to 50 mg (odds ratio = 5.1, 95%CI 1.2 to 22.1; p=0.03). However, the analyses involving 150 mg dose were accompanied by wide confidence intervals due to the small number of cycles using this dosage (n=13), which may limit our interpretation of findings. CONCLUSIONS: Initiation of CC on day 2 resulted in a shorter stimulation phase. Day 2 or day 3 start did not increase the number of recruited follicles. There was a suggested decrease in endometrial thickness with higher doses of CC, regardless of start date. A higher dose of CC (150 mg) was associated with a higher live birth rate." @default.
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• W2073266404 date "2008-09-01" @default.
• W2073266404 modified "2023-09-29" @default.
• W2073266404 title "Effects of initiation day and dose of clomiphene citrate (CC) on cycle parameters and pregnancy rates" @default.
• W2073266404 doi "https://doi.org/10.1016/j.fertnstert.2008.07.1460" @default.
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