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• W2073270298 abstract "We performed molecular dynamics (MD) simulations of hydrated bilayers containing mixtures of dimyristoylphosphatidylcholine (DMPC) and cholesterol at various ratios, to study the effect of cholesterol concentration on its orientation, and to characterize the link between cholesterol tilt and overall phospholipid membrane organization. The simulations show a substantial probability for cholesterol molecules to transiently orient perpendicular to the bilayer normal, and suggest that cholesterol tilt may be an important factor for inducing membrane ordering. In particular, we find that as cholesterol concentration increases (1−40% cholesterol) the average cholesterol orientation changes in a manner strongly (anti)correlated with the variation in membrane thickness. Furthermore, cholesterol orientation is found to be determined by the aligning force exerted by other cholesterol molecules. To quantify this aligning field, we analyzed cholesterol orientation using, to our knowledge, the first estimates of the cholesterol tilt modulus χ from MD simulations. Our calculations suggest that the aligning field that determines χ is indeed strongly linked to sterol composition. This empirical parameter (χ) should therefore become a useful quantitative measure to describe cholesterol interaction with other lipids in bilayers, particularly in various coarse-grained force fields." @default.
• W2073270298 created "2016-06-24" @default.
• W2073270298 creator A5035717943 @default.
• W2073270298 creator A5073788814 @default.
• W2073270298 creator A5080767725 @default.
• W2073270298 date "2010-05-19" @default.
• W2073270298 modified "2023-10-11" @default.
• W2073270298 title "Cholesterol Orientation and Tilt Modulus in DMPC Bilayers" @default.
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• W2073270298 doi "https://doi.org/10.1021/jp101889k" @default.
• W2073270298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2919319" @default.
• W2073270298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20518573" @default.
• W2073270298 hasPublicationYear "2010" @default.
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