FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073272200> ?p ?o ?g. }

• W2073272200 endingPage "590" @default.
• W2073272200 startingPage "581" @default.
• W2073272200 abstract "Reactive oxygen species (ROS) are products of normal cellular metabolism and are known to act as second messengers. Under physiological conditions, ROS participate in maintenance of cellular ‘redox homeostasis’ in order to protect cells against oxidative stress. In addition, regulation of redox state is important for cell activation, viability, proliferation, and organ function. However, overproduction of ROS, most frequently due to excessive stimulation of either reduced nicotinamide adenine dinucleotide phosphate (NADPH) by pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) or the mitochondrial electron transport chain and xanthine oxidase, results in oxidative stress. Oxidative stress is a deleterious process that leads to airway and lung damage and consequently to several respiratory inflammatory diseases/injuries, including acute respiratory distress syndrome (ARDS), asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD). Many of the known inflammatory target proteins, such as matrix metalloproteinase-9 (MMP-9), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2), are associated with NADPH oxidase activation and ROS overproduction in response to pro-inflammatory mediators. Thus, oxidative stress regulates both key inflammatory signal transduction pathways and target proteins involved in airway and lung inflammation. In this review, we discuss mechanisms of NADPH oxidase/ROS in the expression of inflammatory target proteins involved in airway and lung diseases. Knowledge of the mechanisms of ROS regulation could lead to the pharmacological manipulation of antioxidants in airway and lung inflammation and injury." @default.
• W2073272200 created "2016-06-24" @default.
• W2073272200 creator A5031574669 @default.
• W2073272200 creator A5069264476 @default.
• W2073272200 date "2012-09-01" @default.
• W2073272200 modified "2023-10-09" @default.
• W2073272200 title "Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases" @default.
• W2073272200 cites W1524126925 @default.
• W2073272200 cites W1540026419 @default.
• W2073272200 cites W1540220270 @default.
• W2073272200 cites W1793238069 @default.
• W2073272200 cites W1916521535 @default.
• W2073272200 cites W195100871 @default.
• W2073272200 cites W1956874571 @default.
• W2073272200 cites W1963721113 @default.
• W2073272200 cites W1967468829 @default.
• W2073272200 cites W1967681731 @default.
• W2073272200 cites W1970267793 @default.
• W2073272200 cites W1972033007 @default.
• W2073272200 cites W1975282307 @default.
• W2073272200 cites W1980868922 @default.
• W2073272200 cites W1984468751 @default.
• W2073272200 cites W1989494330 @default.
• W2073272200 cites W1994503540 @default.
• W2073272200 cites W1995605818 @default.
• W2073272200 cites W1999105936 @default.
• W2073272200 cites W2000849935 @default.
• W2073272200 cites W2002592591 @default.
• W2073272200 cites W2006192600 @default.
• W2073272200 cites W2011124873 @default.
• W2073272200 cites W2011647595 @default.
• W2073272200 cites W2011993914 @default.
• W2073272200 cites W2015111264 @default.
• W2073272200 cites W2020682518 @default.
• W2073272200 cites W2022031458 @default.
• W2073272200 cites W2025222765 @default.
• W2073272200 cites W2027222787 @default.
• W2073272200 cites W2033147946 @default.
• W2073272200 cites W2035430820 @default.
• W2073272200 cites W2037298238 @default.
• W2073272200 cites W2040421586 @default.
• W2073272200 cites W2042792363 @default.
• W2073272200 cites W2045077089 @default.
• W2073272200 cites W2052525658 @default.
• W2073272200 cites W2053262641 @default.
• W2073272200 cites W2058153300 @default.
• W2073272200 cites W2064359764 @default.
• W2073272200 cites W2065494902 @default.
• W2073272200 cites W2067486887 @default.
• W2073272200 cites W2071948926 @default.
• W2073272200 cites W2079877342 @default.
• W2073272200 cites W2085128107 @default.
• W2073272200 cites W2093950253 @default.
• W2073272200 cites W2099642617 @default.
• W2073272200 cites W2100581807 @default.
• W2073272200 cites W2101745219 @default.
• W2073272200 cites W2102884195 @default.
• W2073272200 cites W2111591597 @default.
• W2073272200 cites W2115846243 @default.
• W2073272200 cites W2119267064 @default.
• W2073272200 cites W2119384867 @default.
• W2073272200 cites W2120940234 @default.
• W2073272200 cites W2125477645 @default.
• W2073272200 cites W2130649466 @default.
• W2073272200 cites W2131518920 @default.
• W2073272200 cites W2131998840 @default.
• W2073272200 cites W2134826076 @default.
• W2073272200 cites W2134866318 @default.
• W2073272200 cites W2141046053 @default.
• W2073272200 cites W2142089445 @default.
• W2073272200 cites W2144477621 @default.
• W2073272200 cites W2147243248 @default.
• W2073272200 cites W2147993424 @default.
• W2073272200 cites W2160967657 @default.
• W2073272200 cites W2164346358 @default.
• W2073272200 cites W2164951630 @default.
• W2073272200 cites W2166044592 @default.
• W2073272200 doi "https://doi.org/10.1016/j.bcp.2012.05.005" @default.
• W2073272200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22587816" @default.
• W2073272200 hasPublicationYear "2012" @default.
• W2073272200 type Work @default.
• W2073272200 sameAs 2073272200 @default.
• W2073272200 citedByCount "340" @default.
• W2073272200 countsByYear W20732722002012 @default.
• W2073272200 countsByYear W20732722002013 @default.
• W2073272200 countsByYear W20732722002014 @default.
• W2073272200 countsByYear W20732722002015 @default.
• W2073272200 countsByYear W20732722002016 @default.
• W2073272200 countsByYear W20732722002017 @default.
• W2073272200 countsByYear W20732722002018 @default.
• W2073272200 countsByYear W20732722002019 @default.
• W2073272200 countsByYear W20732722002020 @default.
• W2073272200 countsByYear W20732722002021 @default.
• W2073272200 countsByYear W20732722002022 @default.
• W2073272200 countsByYear W20732722002023 @default.
• W2073272200 crossrefType "journal-article" @default.
• W2073272200 hasAuthorship W2073272200A5031574669 @default.
• W2073272200 hasAuthorship W2073272200A5069264476 @default.

• next