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- W2073282246 abstract "BackgroundTo establish reproducibility and normal values for fetal liver volume and its significance in identifying fetal growth restriction relative to head (HC) and abdominal circumference (AC) according to a cross-sectional study design.MethodThe measurements were obtained using a Voluson 530-D for volume scanning. The coefficient of variation (CV) for liver volume scans (t0, t20 min) and liver area tracings (t0: 2x; t20: 2x) was determined (n: 20; 23–36 weeks). Normal charts for liver volume, HC, AC were constructed (n: 60; 22–37 weeks) and related to data from growth-restricted fetuses (birthweight < P5) (n: 13; 23–36 weeks).ResultsCV is 2.9% for volume scans and 1.6% for area tracings. Mean liver volume (P50) ranges between 16.5 mL (± 5.9 (SD)) at 22 weeks and 101.8 mL (± 8.2 (SD)) at 37 weeks. In fetal growth restriction, liver volume, HC and AC expressed as percentage of the normal P50 is 45%, 91% and 83%, respectively. Mean difference in liver size between fetal growth restriction (FGR) and normal fetal development (Z score = Liver volumeFGR– P50normal/SDnormal) is −4.5 ± 1.6 (SD), which is significantly different (P < 0.05) from HC: − 3.2 ± 1.5 (SD), but not from AC: − 4.3 ± 1.3 (SD).ConclusionAcceptable reproducibility exists for liver volume determinations. Normal liver volume increases 6-fold at 22–37 weeks. Fetal growth restriction: reduction is more pronounced for liver volume than HC and AC; liver volume is a better discriminator than HC, but not AC." @default.
- W2073282246 created "2016-06-24" @default.
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- W2073282246 date "2000-10-01" @default.
- W2073282246 modified "2023-09-24" @default.
- W2073282246 title "P21Fetal liver volume in normal and reduced fetal growth" @default.
- W2073282246 doi "https://doi.org/10.1046/j.1469-0705.2000.00004-1-21.x" @default.
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