Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073282913> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2073282913 endingPage "37" @default.
- W2073282913 startingPage "35" @default.
- W2073282913 abstract "Outcomes in clinical islet transplantation improved substantially with the introduction of combined sirolimus and tacrolimus immunosuppression. However, multiple islet preparations are often required to achieve insulin independence, suggesting that islet engraftment may not be optimal when these agents are absorbed via the portal vein. The current study was designed to assess the differential concentrations of immunosuppressive drugs within the portal and systemic circulations of a large animal model, to assess the local concentrations of drugs to which islets are exposed early after implantation. Chronic catheters were placed in the portal vein and carotid artery of 6 mongrel dogs, and immunosuppressants were administered orally. Blood samples were drawn simultaneously from portal and systemic catheters, and drug concentrations were analyzed. Peak immunosuppressant levels as well as area under the curve were dramatically elevated in portal blood relative to systemic levels for all drugs tested. This portal storm of immunosuppression may be relevant to intrahepatic islet transplantation." @default.
- W2073282913 created "2016-06-24" @default.
- W2073282913 creator A5011852495 @default.
- W2073282913 creator A5033480784 @default.
- W2073282913 creator A5048893633 @default.
- W2073282913 creator A5066178885 @default.
- W2073282913 creator A5067408895 @default.
- W2073282913 creator A5084980691 @default.
- W2073282913 creator A5085334380 @default.
- W2073282913 creator A5090988731 @default.
- W2073282913 date "2005-02-01" @default.
- W2073282913 modified "2023-10-11" @default.
- W2073282913 title "The Portal Immunosuppressive Storm" @default.
- W2073282913 cites W1966051569 @default.
- W2073282913 cites W1975545753 @default.
- W2073282913 cites W1998181395 @default.
- W2073282913 cites W2016728354 @default.
- W2073282913 cites W2041496770 @default.
- W2073282913 cites W2044761044 @default.
- W2073282913 cites W2073192748 @default.
- W2073282913 cites W2163652885 @default.
- W2073282913 cites W2328786770 @default.
- W2073282913 doi "https://doi.org/10.1097/00007691-200502000-00008" @default.
- W2073282913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15665744" @default.
- W2073282913 hasPublicationYear "2005" @default.
- W2073282913 type Work @default.
- W2073282913 sameAs 2073282913 @default.
- W2073282913 citedByCount "120" @default.
- W2073282913 countsByYear W20732829132012 @default.
- W2073282913 countsByYear W20732829132013 @default.
- W2073282913 countsByYear W20732829132014 @default.
- W2073282913 countsByYear W20732829132015 @default.
- W2073282913 countsByYear W20732829132016 @default.
- W2073282913 countsByYear W20732829132017 @default.
- W2073282913 countsByYear W20732829132019 @default.
- W2073282913 countsByYear W20732829132020 @default.
- W2073282913 countsByYear W20732829132021 @default.
- W2073282913 countsByYear W20732829132022 @default.
- W2073282913 countsByYear W20732829132023 @default.
- W2073282913 crossrefType "journal-article" @default.
- W2073282913 hasAuthorship W2073282913A5011852495 @default.
- W2073282913 hasAuthorship W2073282913A5033480784 @default.
- W2073282913 hasAuthorship W2073282913A5048893633 @default.
- W2073282913 hasAuthorship W2073282913A5066178885 @default.
- W2073282913 hasAuthorship W2073282913A5067408895 @default.
- W2073282913 hasAuthorship W2073282913A5084980691 @default.
- W2073282913 hasAuthorship W2073282913A5085334380 @default.
- W2073282913 hasAuthorship W2073282913A5090988731 @default.
- W2073282913 hasConcept C126322002 @default.
- W2073282913 hasConcept C165220095 @default.
- W2073282913 hasConcept C2779033008 @default.
- W2073282913 hasConcept C2779306644 @default.
- W2073282913 hasConcept C2779609443 @default.
- W2073282913 hasConcept C2780252810 @default.
- W2073282913 hasConcept C2909675724 @default.
- W2073282913 hasConcept C2911091166 @default.
- W2073282913 hasConcept C71924100 @default.
- W2073282913 hasConcept C98274493 @default.
- W2073282913 hasConceptScore W2073282913C126322002 @default.
- W2073282913 hasConceptScore W2073282913C165220095 @default.
- W2073282913 hasConceptScore W2073282913C2779033008 @default.
- W2073282913 hasConceptScore W2073282913C2779306644 @default.
- W2073282913 hasConceptScore W2073282913C2779609443 @default.
- W2073282913 hasConceptScore W2073282913C2780252810 @default.
- W2073282913 hasConceptScore W2073282913C2909675724 @default.
- W2073282913 hasConceptScore W2073282913C2911091166 @default.
- W2073282913 hasConceptScore W2073282913C71924100 @default.
- W2073282913 hasConceptScore W2073282913C98274493 @default.
- W2073282913 hasIssue "1" @default.
- W2073282913 hasLocation W20732829131 @default.
- W2073282913 hasLocation W20732829132 @default.
- W2073282913 hasOpenAccess W2073282913 @default.
- W2073282913 hasPrimaryLocation W20732829131 @default.
- W2073282913 hasRelatedWork W2003921494 @default.
- W2073282913 hasRelatedWork W2039925961 @default.
- W2073282913 hasRelatedWork W2057461145 @default.
- W2073282913 hasRelatedWork W2249561979 @default.
- W2073282913 hasRelatedWork W2412248251 @default.
- W2073282913 hasRelatedWork W2482706579 @default.
- W2073282913 hasRelatedWork W3150855330 @default.
- W2073282913 hasRelatedWork W3207196874 @default.
- W2073282913 hasRelatedWork W4200557508 @default.
- W2073282913 hasRelatedWork W4320041232 @default.
- W2073282913 hasVolume "27" @default.
- W2073282913 isParatext "false" @default.
- W2073282913 isRetracted "false" @default.
- W2073282913 magId "2073282913" @default.
- W2073282913 workType "article" @default.