FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073283337> ?p ?o ?g. }

• W2073283337 endingPage "138" @default.
• W2073283337 startingPage "133" @default.
• W2073283337 abstract "Soybean Bowman-Birk protease inhibitor (BBI) is an inhibitor of serine proteases with two functional inhibitory domains of different specificities: one is specific for chymotrypsin-like proteases, the other for trypsin-like proteases. Chymase and tryptase are serine proteases which are stored in mast cell granules and released upon degranulation. This work investigated the inhibition of human chymase and tryptase by BBI. Active-site titration of human skin chymase by BBI demonstrated that BBI was a highly effective inhibitor of human chymase. Virtually stoichiometric inhibition of chymase by BBI was observed at 10 nM chymase. Kinetic studies of the inhibition reaction yielded an association rate constant of 4.0 x 10(5) M(-1) s(-1) and a dissociation rate constant of 1.7 x 10(-5) s(-1). From these two constants we estimate a K(i) of 50 pM. Chymase/BBI complexes did not dissociate in SDS-PAGE analyses under nonreducing conditions, consistent with the formation of a very tight complex with little tendency to dissociate. In contrast to chymase, human tryptase was not inhibited by BBI. These studies demonstrate that BBI is a good inhibitor of human chymase, exhibiting reaction properties better than physiological inhibitors described to date." @default.
• W2073283337 created "2016-06-24" @default.
• W2073283337 creator A5000644404 @default.
• W2073283337 creator A5014032746 @default.
• W2073283337 creator A5051987821 @default.
• W2073283337 creator A5067787438 @default.
• W2073283337 creator A5075478892 @default.
• W2073283337 date "1997-08-01" @default.
• W2073283337 modified "2023-09-25" @default.
• W2073283337 title "Soybean Bowman–Birk Protease Inhibitor Is a Highly Effective Inhibitor of Human Mast Cell Chymase" @default.
• W2073283337 cites W1549183351 @default.
• W2073283337 cites W1558266500 @default.
• W2073283337 cites W1563535758 @default.
• W2073283337 cites W1582826730 @default.
• W2073283337 cites W1582901166 @default.
• W2073283337 cites W1588568089 @default.
• W2073283337 cites W1600920155 @default.
• W2073283337 cites W1625181872 @default.
• W2073283337 cites W1796406008 @default.
• W2073283337 cites W183064 @default.
• W2073283337 cites W1967994985 @default.
• W2073283337 cites W1971971681 @default.
• W2073283337 cites W1986590322 @default.
• W2073283337 cites W1993094156 @default.
• W2073283337 cites W1993585253 @default.
• W2073283337 cites W2004636370 @default.
• W2073283337 cites W2020553724 @default.
• W2073283337 cites W2021004569 @default.
• W2073283337 cites W2051988900 @default.
• W2073283337 cites W2081278774 @default.
• W2073283337 cites W2083516710 @default.
• W2073283337 cites W2100837269 @default.
• W2073283337 cites W2127025854 @default.
• W2073283337 cites W2143658570 @default.
• W2073283337 cites W2325551892 @default.
• W2073283337 cites W2419564780 @default.
• W2073283337 cites W4237036580 @default.
• W2073283337 doi "https://doi.org/10.1006/abbi.1997.0182" @default.
• W2073283337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9244390" @default.
• W2073283337 hasPublicationYear "1997" @default.
• W2073283337 type Work @default.
• W2073283337 sameAs 2073283337 @default.
• W2073283337 citedByCount "71" @default.
• W2073283337 countsByYear W20732833372012 @default.
• W2073283337 countsByYear W20732833372013 @default.
• W2073283337 countsByYear W20732833372014 @default.
• W2073283337 countsByYear W20732833372015 @default.
• W2073283337 countsByYear W20732833372016 @default.
• W2073283337 countsByYear W20732833372017 @default.
• W2073283337 countsByYear W20732833372018 @default.
• W2073283337 countsByYear W20732833372019 @default.
• W2073283337 countsByYear W20732833372020 @default.
• W2073283337 countsByYear W20732833372021 @default.
• W2073283337 countsByYear W20732833372022 @default.
• W2073283337 crossrefType "journal-article" @default.
• W2073283337 hasAuthorship W2073283337A5000644404 @default.
• W2073283337 hasAuthorship W2073283337A5014032746 @default.
• W2073283337 hasAuthorship W2073283337A5051987821 @default.
• W2073283337 hasAuthorship W2073283337A5067787438 @default.
• W2073283337 hasAuthorship W2073283337A5075478892 @default.
• W2073283337 hasBestOaLocation W20732833371 @default.
• W2073283337 hasConcept C142462285 @default.
• W2073283337 hasConcept C153911025 @default.
• W2073283337 hasConcept C181199279 @default.
• W2073283337 hasConcept C182220744 @default.
• W2073283337 hasConcept C185592680 @default.
• W2073283337 hasConcept C203014093 @default.
• W2073283337 hasConcept C2776414213 @default.
• W2073283337 hasConcept C2776714187 @default.
• W2073283337 hasConcept C2776980637 @default.
• W2073283337 hasConcept C2777807008 @default.
• W2073283337 hasConcept C2778401398 @default.
• W2073283337 hasConcept C2779726688 @default.
• W2073283337 hasConcept C2780340462 @default.
• W2073283337 hasConcept C2780614898 @default.
• W2073283337 hasConcept C2781143361 @default.
• W2073283337 hasConcept C2781406822 @default.
• W2073283337 hasConcept C2993143319 @default.
• W2073283337 hasConcept C3013748606 @default.
• W2073283337 hasConcept C55493867 @default.
• W2073283337 hasConcept C86803240 @default.
• W2073283337 hasConceptScore W2073283337C142462285 @default.
• W2073283337 hasConceptScore W2073283337C153911025 @default.
• W2073283337 hasConceptScore W2073283337C181199279 @default.
• W2073283337 hasConceptScore W2073283337C182220744 @default.
• W2073283337 hasConceptScore W2073283337C185592680 @default.
• W2073283337 hasConceptScore W2073283337C203014093 @default.
• W2073283337 hasConceptScore W2073283337C2776414213 @default.
• W2073283337 hasConceptScore W2073283337C2776714187 @default.
• W2073283337 hasConceptScore W2073283337C2776980637 @default.
• W2073283337 hasConceptScore W2073283337C2777807008 @default.
• W2073283337 hasConceptScore W2073283337C2778401398 @default.
• W2073283337 hasConceptScore W2073283337C2779726688 @default.
• W2073283337 hasConceptScore W2073283337C2780340462 @default.
• W2073283337 hasConceptScore W2073283337C2780614898 @default.
• W2073283337 hasConceptScore W2073283337C2781143361 @default.
• W2073283337 hasConceptScore W2073283337C2781406822 @default.
• W2073283337 hasConceptScore W2073283337C2993143319 @default.

• next