Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073285446> ?p ?o ?g. }
- W2073285446 endingPage "238" @default.
- W2073285446 startingPage "233" @default.
- W2073285446 abstract "Beta-amyloid protein (betaAP) is thought to cause neuronal loss in Alzheimer's disease (AD). Applied to neurons in culture, betaAP induces neuronal death and hyperphosphorylation of tau protein, which forms neurofibrillary tangles (NFTs) in AD brains. Neurons also undergo rapid apoptotic death following reactivation of a mitotic cycle. However, the molecular events that determine the fate of neurons challenged with betaAP (apoptotic death, formation of NFTs and survival) are unclear. We discuss a scenario for the pathogenesis of AD. This links betaAP-induced changes to the Wnt signaling pathway that promotes proliferation of progenitor cells and directs cells into a neuronal phenotype during brain development. We propose that betaAP-mediated facilitation of mitogenic Wnt signaling activates unscheduled mitosis in differentiated neurons. Furthermore, late downregulation of Wnt signaling by betaAP might lead to NFT formation. We propose that drugs that both inhibit the cell cycle and rescue Wnt activity could provide novel AD therapeutics." @default.
- W2073285446 created "2016-06-24" @default.
- W2073285446 creator A5009749251 @default.
- W2073285446 creator A5017478342 @default.
- W2073285446 creator A5039055702 @default.
- W2073285446 creator A5052663815 @default.
- W2073285446 creator A5056468131 @default.
- W2073285446 creator A5062403608 @default.
- W2073285446 creator A5068147978 @default.
- W2073285446 creator A5082099245 @default.
- W2073285446 date "2003-05-01" @default.
- W2073285446 modified "2023-10-10" @default.
- W2073285446 title "The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease?" @default.
- W2073285446 cites W1495997476 @default.
- W2073285446 cites W1546972840 @default.
- W2073285446 cites W1564357553 @default.
- W2073285446 cites W1577877616 @default.
- W2073285446 cites W1582530914 @default.
- W2073285446 cites W1780615788 @default.
- W2073285446 cites W1935475606 @default.
- W2073285446 cites W1935951477 @default.
- W2073285446 cites W1939092506 @default.
- W2073285446 cites W1981105329 @default.
- W2073285446 cites W1983435458 @default.
- W2073285446 cites W1983594867 @default.
- W2073285446 cites W1990079403 @default.
- W2073285446 cites W1995925086 @default.
- W2073285446 cites W2006718453 @default.
- W2073285446 cites W2009143228 @default.
- W2073285446 cites W2009646199 @default.
- W2073285446 cites W2011328869 @default.
- W2073285446 cites W2015897319 @default.
- W2073285446 cites W2015964634 @default.
- W2073285446 cites W2019802189 @default.
- W2073285446 cites W2020977918 @default.
- W2073285446 cites W2021464180 @default.
- W2073285446 cites W2024977010 @default.
- W2073285446 cites W2032924726 @default.
- W2073285446 cites W2047514208 @default.
- W2073285446 cites W2049105252 @default.
- W2073285446 cites W2051036729 @default.
- W2073285446 cites W2058085247 @default.
- W2073285446 cites W2059408944 @default.
- W2073285446 cites W2065691470 @default.
- W2073285446 cites W2084957666 @default.
- W2073285446 cites W2085077704 @default.
- W2073285446 cites W2092235352 @default.
- W2073285446 cites W2096410114 @default.
- W2073285446 cites W2104373322 @default.
- W2073285446 cites W2113476104 @default.
- W2073285446 cites W2114358785 @default.
- W2073285446 cites W2118771226 @default.
- W2073285446 cites W2125904354 @default.
- W2073285446 cites W2131108901 @default.
- W2073285446 cites W2137395552 @default.
- W2073285446 cites W2159561886 @default.
- W2073285446 cites W2168626405 @default.
- W2073285446 cites W4236286061 @default.
- W2073285446 cites W4293021036 @default.
- W2073285446 cites W4322703206 @default.
- W2073285446 cites W754177916 @default.
- W2073285446 doi "https://doi.org/10.1016/s0165-6147(03)00100-7" @default.
- W2073285446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12767722" @default.
- W2073285446 hasPublicationYear "2003" @default.
- W2073285446 type Work @default.
- W2073285446 sameAs 2073285446 @default.
- W2073285446 citedByCount "120" @default.
- W2073285446 countsByYear W20732854462012 @default.
- W2073285446 countsByYear W20732854462013 @default.
- W2073285446 countsByYear W20732854462014 @default.
- W2073285446 countsByYear W20732854462015 @default.
- W2073285446 countsByYear W20732854462016 @default.
- W2073285446 countsByYear W20732854462017 @default.
- W2073285446 countsByYear W20732854462019 @default.
- W2073285446 countsByYear W20732854462020 @default.
- W2073285446 countsByYear W20732854462022 @default.
- W2073285446 countsByYear W20732854462023 @default.
- W2073285446 crossrefType "journal-article" @default.
- W2073285446 hasAuthorship W2073285446A5009749251 @default.
- W2073285446 hasAuthorship W2073285446A5017478342 @default.
- W2073285446 hasAuthorship W2073285446A5039055702 @default.
- W2073285446 hasAuthorship W2073285446A5052663815 @default.
- W2073285446 hasAuthorship W2073285446A5056468131 @default.
- W2073285446 hasAuthorship W2073285446A5062403608 @default.
- W2073285446 hasAuthorship W2073285446A5068147978 @default.
- W2073285446 hasAuthorship W2073285446A5082099245 @default.
- W2073285446 hasConcept C104317684 @default.
- W2073285446 hasConcept C11960822 @default.
- W2073285446 hasConcept C127561419 @default.
- W2073285446 hasConcept C137620995 @default.
- W2073285446 hasConcept C142724271 @default.
- W2073285446 hasConcept C169760540 @default.
- W2073285446 hasConcept C190283241 @default.
- W2073285446 hasConcept C201750760 @default.
- W2073285446 hasConcept C2776156579 @default.
- W2073285446 hasConcept C2778198054 @default.
- W2073285446 hasConcept C2778670691 @default.
- W2073285446 hasConcept C2779134260 @default.