FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073285464> ?p ?o ?g. }

• W2073285464 endingPage "10" @default.
• W2073285464 startingPage "1" @default.
• W2073285464 abstract "The serpins (serine proteinase inhibitors) are structurally similar but functionally diverse proteins that fold into a conserved structure and employ a unique suicide substrate-like inhibitory mechanism. Serpins play absolutely critical role in the control of proteases involved in the inflammatory, complement, coagulation and fibrinolytic pathways and are associated with many conformational diseases. Serpin's native state is a metastable state which transforms to a more stable state during its inhibitory mechanism. Serpin in the native form is in the stressed (S) conformation that undergoes a transition to a relaxed (R) conformation for the protease inhibition. During this transition the region called as reactive center loop which interacts with target proteases, inserts itself into the center of β-sheet A to form an extra strand. Serpin is delicately balanced to perform its function with many critical residues involved in maintaining metastability. However due to its typical mechanism of inhibition, naturally occurring serpin variants produces conformational instability that allows insertion of RCL of one molecule into the β-sheet A of another to form a loop-sheet linkage leading to its polymerization and aggregation. Thus understanding the molecular basis and amino acid involved in serpin polymerization mechanism is critical to devising strategies for its cure." @default.
• W2073285464 created "2016-06-24" @default.
• W2073285464 creator A5007389853 @default.
• W2073285464 creator A5042967257 @default.
• W2073285464 creator A5046083621 @default.
• W2073285464 creator A5074103208 @default.
• W2073285464 creator A5080627913 @default.
• W2073285464 creator A5083795351 @default.
• W2073285464 creator A5084168406 @default.
• W2073285464 date "2011-05-24" @default.
• W2073285464 modified "2023-10-01" @default.
• W2073285464 title "Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization" @default.
• W2073285464 cites W1493993231 @default.
• W2073285464 cites W1494517489 @default.
• W2073285464 cites W1497473690 @default.
• W2073285464 cites W1509912507 @default.
• W2073285464 cites W1520644305 @default.
• W2073285464 cites W1562752364 @default.
• W2073285464 cites W1571398079 @default.
• W2073285464 cites W157827487 @default.
• W2073285464 cites W1583012020 @default.
• W2073285464 cites W1645568321 @default.
• W2073285464 cites W1968644977 @default.
• W2073285464 cites W1978261862 @default.
• W2073285464 cites W1984839844 @default.
• W2073285464 cites W1994767400 @default.
• W2073285464 cites W2001177661 @default.
• W2073285464 cites W2008405604 @default.
• W2073285464 cites W2009420807 @default.
• W2073285464 cites W2009517326 @default.
• W2073285464 cites W2011235223 @default.
• W2073285464 cites W2013474205 @default.
• W2073285464 cites W2015989266 @default.
• W2073285464 cites W2016977751 @default.
• W2073285464 cites W2016997461 @default.
• W2073285464 cites W2023497694 @default.
• W2073285464 cites W2031007165 @default.
• W2073285464 cites W2032615313 @default.
• W2073285464 cites W2036057713 @default.
• W2073285464 cites W2038907761 @default.
• W2073285464 cites W2041397397 @default.
• W2073285464 cites W2045090247 @default.
• W2073285464 cites W2047947037 @default.
• W2073285464 cites W2048262707 @default.
• W2073285464 cites W2058902820 @default.
• W2073285464 cites W2061346634 @default.
• W2073285464 cites W2061861422 @default.
• W2073285464 cites W2062496325 @default.
• W2073285464 cites W2067114452 @default.
• W2073285464 cites W2071363357 @default.
• W2073285464 cites W2071607613 @default.
• W2073285464 cites W2073457036 @default.
• W2073285464 cites W2075106828 @default.
• W2073285464 cites W2076540674 @default.
• W2073285464 cites W2078119200 @default.
• W2073285464 cites W2081971813 @default.
• W2073285464 cites W2082893484 @default.
• W2073285464 cites W2083120544 @default.
• W2073285464 cites W2086487704 @default.
• W2073285464 cites W2087835153 @default.
• W2073285464 cites W2094962117 @default.
• W2073285464 cites W2115888129 @default.
• W2073285464 cites W2123496533 @default.
• W2073285464 cites W2133420109 @default.
• W2073285464 cites W2142336601 @default.
• W2073285464 cites W2146339607 @default.
• W2073285464 cites W2148114644 @default.
• W2073285464 cites W2170327826 @default.
• W2073285464 cites W2171215167 @default.
• W2073285464 cites W2410932178 @default.
• W2073285464 cites W4241211894 @default.
• W2073285464 doi "https://doi.org/10.4061/2011/606797" @default.
• W2073285464 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3268027" @default.
• W2073285464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22312466" @default.
• W2073285464 hasPublicationYear "2011" @default.
• W2073285464 type Work @default.
• W2073285464 sameAs 2073285464 @default.
• W2073285464 citedByCount "64" @default.
• W2073285464 countsByYear W20732854642012 @default.
• W2073285464 countsByYear W20732854642013 @default.
• W2073285464 countsByYear W20732854642015 @default.
• W2073285464 countsByYear W20732854642016 @default.
• W2073285464 countsByYear W20732854642017 @default.
• W2073285464 countsByYear W20732854642018 @default.
• W2073285464 countsByYear W20732854642019 @default.
• W2073285464 countsByYear W20732854642020 @default.
• W2073285464 countsByYear W20732854642021 @default.
• W2073285464 countsByYear W20732854642022 @default.
• W2073285464 countsByYear W20732854642023 @default.
• W2073285464 crossrefType "journal-article" @default.
• W2073285464 hasAuthorship W2073285464A5007389853 @default.
• W2073285464 hasAuthorship W2073285464A5042967257 @default.
• W2073285464 hasAuthorship W2073285464A5046083621 @default.
• W2073285464 hasAuthorship W2073285464A5074103208 @default.
• W2073285464 hasAuthorship W2073285464A5080627913 @default.
• W2073285464 hasAuthorship W2073285464A5083795351 @default.
• W2073285464 hasAuthorship W2073285464A5084168406 @default.
• W2073285464 hasBestOaLocation W20732854641 @default.

• next