FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073286303> ?p ?o ?g. }

• W2073286303 endingPage "3368" @default.
• W2073286303 startingPage "3358" @default.
• W2073286303 abstract "There is a dearth in fundamental cellular-level understanding of how nanoparticles interact with the cells of the blood brain barrier (BBB), particularly under the oxidative environment. The apoptosis of cerebral microvessel endothelial cells (CMECs) induced by oxidative stress injury plays a key role in the dysfunction of BBB. By use of CMECs as an in vitro BBB model, we show for the first time that C60(C(COOH)2)2 nanoparticles can selectively enter oxidized CMECs rather than normal cells, and maintain CMECs integrity by attenuating H2O2-induced F-actin depolymerization via the observation of several state-of-the art microscopic techniques. Additionally, we have found that C60(C(COOH)2)2 nanoparticles greatly inhibit the apoptosis of CMECs induced by H2O2, which is related to their modulation of the JNK pathway. C60(C(COOH)2)2 nanoparticles can regulate several downstream signaling events related to the JNK pathway, including reduction of JNK phosphorylation, activation of activator protein 1 (AP-1) and caspase-3, and inhibition of polyADP-ribose polymerase (PARP) cleavage and mitochondrial cytochrome c release. Our results indicate that C60(C(COOH)2)2 nanoparticles possess a novel ability of selectively entering oxidation-damaged cerebral endothelial cells rather than normal endothelial cells and then protecting them from apoptosis." @default.
• W2073286303 created "2016-06-24" @default.
• W2073286303 creator A5000432967 @default.
• W2073286303 creator A5000920529 @default.
• W2073286303 creator A5012324763 @default.
• W2073286303 creator A5035192507 @default.
• W2073286303 creator A5040060805 @default.
• W2073286303 creator A5054199475 @default.
• W2073286303 creator A5073108451 @default.
• W2073286303 creator A5081031339 @default.
• W2073286303 creator A5088951751 @default.
• W2073286303 date "2009-10-19" @default.
• W2073286303 modified "2023-10-14" @default.
• W2073286303 title "Fullerene Nanoparticles Selectively Enter Oxidation-Damaged Cerebral Microvessel Endothelial Cells and Inhibit JNK-Related Apoptosis" @default.
• W2073286303 cites W163606371 @default.
• W2073286303 cites W1966725539 @default.
• W2073286303 cites W1972077999 @default.
• W2073286303 cites W1978538970 @default.
• W2073286303 cites W1979368709 @default.
• W2073286303 cites W1981314240 @default.
• W2073286303 cites W1981425827 @default.
• W2073286303 cites W1986420231 @default.
• W2073286303 cites W1988740018 @default.
• W2073286303 cites W1993560527 @default.
• W2073286303 cites W2010312001 @default.
• W2073286303 cites W2013456954 @default.
• W2073286303 cites W2018235831 @default.
• W2073286303 cites W2036678992 @default.
• W2073286303 cites W2038735819 @default.
• W2073286303 cites W2045786028 @default.
• W2073286303 cites W2057041797 @default.
• W2073286303 cites W2060457554 @default.
• W2073286303 cites W2062412222 @default.
• W2073286303 cites W2067072091 @default.
• W2073286303 cites W2068491059 @default.
• W2073286303 cites W2069774840 @default.
• W2073286303 cites W2076485183 @default.
• W2073286303 cites W2080068413 @default.
• W2073286303 cites W2086301846 @default.
• W2073286303 cites W2097016322 @default.
• W2073286303 cites W2098677114 @default.
• W2073286303 cites W2103056710 @default.
• W2073286303 cites W2104983190 @default.
• W2073286303 cites W2105077859 @default.
• W2073286303 cites W2107045256 @default.
• W2073286303 cites W2107854895 @default.
• W2073286303 cites W2119115109 @default.
• W2073286303 cites W2122074407 @default.
• W2073286303 cites W2123619121 @default.
• W2073286303 cites W2126036130 @default.
• W2073286303 cites W2127986970 @default.
• W2073286303 cites W2135372251 @default.
• W2073286303 cites W2341370789 @default.
• W2073286303 cites W4232403845 @default.
• W2073286303 doi "https://doi.org/10.1021/nn900912n" @default.
• W2073286303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19839607" @default.
• W2073286303 hasPublicationYear "2009" @default.
• W2073286303 type Work @default.
• W2073286303 sameAs 2073286303 @default.
• W2073286303 citedByCount "117" @default.
• W2073286303 countsByYear W20732863032012 @default.
• W2073286303 countsByYear W20732863032013 @default.
• W2073286303 countsByYear W20732863032014 @default.
• W2073286303 countsByYear W20732863032015 @default.
• W2073286303 countsByYear W20732863032016 @default.
• W2073286303 countsByYear W20732863032017 @default.
• W2073286303 countsByYear W20732863032018 @default.
• W2073286303 countsByYear W20732863032019 @default.
• W2073286303 countsByYear W20732863032020 @default.
• W2073286303 countsByYear W20732863032021 @default.
• W2073286303 countsByYear W20732863032022 @default.
• W2073286303 countsByYear W20732863032023 @default.
• W2073286303 crossrefType "journal-article" @default.
• W2073286303 hasAuthorship W2073286303A5000432967 @default.
• W2073286303 hasAuthorship W2073286303A5000920529 @default.
• W2073286303 hasAuthorship W2073286303A5012324763 @default.
• W2073286303 hasAuthorship W2073286303A5035192507 @default.
• W2073286303 hasAuthorship W2073286303A5040060805 @default.
• W2073286303 hasAuthorship W2073286303A5054199475 @default.
• W2073286303 hasAuthorship W2073286303A5073108451 @default.
• W2073286303 hasAuthorship W2073286303A5081031339 @default.
• W2073286303 hasAuthorship W2073286303A5088951751 @default.
• W2073286303 hasConcept C104317684 @default.
• W2073286303 hasConcept C11960822 @default.
• W2073286303 hasConcept C12554922 @default.
• W2073286303 hasConcept C182979987 @default.
• W2073286303 hasConcept C185592680 @default.
• W2073286303 hasConcept C190283241 @default.
• W2073286303 hasConcept C22615655 @default.
• W2073286303 hasConcept C2776151105 @default.
• W2073286303 hasConcept C2776436680 @default.
• W2073286303 hasConcept C2780394083 @default.
• W2073286303 hasConcept C28859421 @default.
• W2073286303 hasConcept C29311851 @default.
• W2073286303 hasConcept C502942594 @default.
• W2073286303 hasConcept C54009773 @default.
• W2073286303 hasConcept C552990157 @default.
• W2073286303 hasConcept C55493867 @default.

• next