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• W2073293514 abstract "Propofol sedation is often used in intensive care patients. Many functions of the immune system are depressed after anaesthesia and severe trauma. Propofol has been found to reduce the proliferative response of lymphocytes in intensive care patients and cause hyperlipidaemia, hypertriglyceridaemia, neurological complications and metabolic acidosis. The mechanism of these adverse effects is not well known. The aim of this study was to investigate the extent, if any, to which propofol anaesthesia can compromise the immune response in the peripheral microcirculation and the final outcome of surgical procedures. The cremaster muscle flap model for intravital microscopic studies was used. Fourteen male Sprague-Dawley rats were studied. Group I halothane anaesthesia (n=6). Following induction with pentobarbitone 40 mg kg−1 i.p., the trachea was intubated and the lungs were ventilated with halothane (2 MAC) and oxygen (FiO2=0.35) at a respiratory rate and tidal volume sufficient to maintain PaCO2 at 5.2+0.5 KPa. Group II propofol anaesthesia (n=8). Following induction with pentobarbitone, the femoral vein was cannulated and propofol anaesthesia (2.5 mg kg−1 h−1) was maintained via a continuous infusion pump. The following vital signs were monitored: MAP, CVP, ECG, pH, PaCO2 and PaO2. The cremaster muscle flap was isolated on a neurovascular pedicle, and prepared for 4 h of intravital microscopic measurements of vessel diameters, RBC velocities (optical Doppler velocimeter), leucocyte and lymphocyte activation (rollers, stickers and transmigrating WBC), endothelial oedema index and capillary perfusion. When compared with halothane, during the first hour of propofol anaesthesia, rolling leucocytes increased by 57.2% (P<0.05). However, after 4 h, a significant drop (96.6%) in the number of circulating leucocytes was found in the propofol group (P<0.05). This was accompanied by 122.8% increase in transmigrating leucocytes, 6.5% rise in endothelial oedema index and a significant (34.1%) decrease in capillary perfusion (P<0.05). The most striking finding was the over 20-fold 'increase' in the lymphocytic activation during propofol anaesthesia. In this study propofol anaesthesia proved to significantly alter leucocyte function by decreasing the total number of PMNs and by increasing the adhesive properties of the leucocytes. The unexpected surge of lymphocytic activation may further suggest immuno-suppressive effect of this agent and should be considered when propofol is used in immuno-compromised patients and in patients exposed to severe trauma." @default.
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• W2073293514 date "1997-09-01" @default.
• W2073293514 modified "2023-09-25" @default.
• W2073293514 title "Leucocyte and lymphocyte behaviour in peripheral microcirculation under propofol and halothane anaesthesia" @default.
• W2073293514 doi "https://doi.org/10.1097/00003643-199709000-00045" @default.
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