FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073293886> ?p ?o ?g. }

• W2073293886 endingPage "182" @default.
• W2073293886 startingPage "177" @default.
• W2073293886 abstract "In decerebrated rats, we determined the dose of A803467, a NaV 1.8 antagonist, needed to attenuate the reflex pressor responses to femoral arterial injections of lactic acid (24 mM; ~0.1 ml) and capsaicin (0.1 μg), agents which stimulate thin fiber afferents having NaV 1.8 channels. We also determined whether the dose of A803467 needed to attenuate these reflex responses affected the responses of muscle spindle afferents to tendon stretch and succinylcholine (200 μg). Spindle afferents are not supplied with NaV 1.8 channels, and consequently their responses to these stimuli should not be influenced by A803467. Pressor responses to lactic acid and capsaicin were not altered by 500 μg of A803467 (n = 6). A803467 in a dose of 1 mg, however, significantly reduced (p < 0.05; n = 12) the pressor responses to lactic acid (23 ± 5 to 7 ± 3Δ mmHg) and capsaicin (47 ± 5 to 31 ± 5Δ mmHg). Surprisingly, we also found that 1 mg of A803467 reduced the responses of 10 spindle afferents to succinylcholine (34 ± 11 to 4 ± 3Δ imp/s; p < 0.05) and stretch (83 ± 17 to 0.4 ± 1Δ imp/s; p < 0.05). We conclude that A803467 reduces the reflex response to lactic acid and capsaicin; however, it may be working on multiple channels, including NaV 1.8, other NaVs as well as voltage-gated calcium channels." @default.
• W2073293886 created "2016-06-24" @default.
• W2073293886 creator A5000184662 @default.
• W2073293886 creator A5004382964 @default.
• W2073293886 creator A5049723883 @default.
• W2073293886 creator A5067322530 @default.
• W2073293886 creator A5091881806 @default.
• W2073293886 date "2013-05-01" @default.
• W2073293886 modified "2023-10-18" @default.
• W2073293886 title "Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels" @default.
• W2073293886 cites W1511198581 @default.
• W2073293886 cites W1896668466 @default.
• W2073293886 cites W1907866259 @default.
• W2073293886 cites W1959515649 @default.
• W2073293886 cites W1992818845 @default.
• W2073293886 cites W2008465842 @default.
• W2073293886 cites W2021504105 @default.
• W2073293886 cites W2029775320 @default.
• W2073293886 cites W2034194515 @default.
• W2073293886 cites W2034721936 @default.
• W2073293886 cites W2048805953 @default.
• W2073293886 cites W2049710812 @default.
• W2073293886 cites W2049952694 @default.
• W2073293886 cites W2051109362 @default.
• W2073293886 cites W2059526536 @default.
• W2073293886 cites W2059771125 @default.
• W2073293886 cites W2063835667 @default.
• W2073293886 cites W2069763385 @default.
• W2073293886 cites W2076923772 @default.
• W2073293886 cites W2079576606 @default.
• W2073293886 cites W2088929593 @default.
• W2073293886 cites W2089842487 @default.
• W2073293886 cites W2095971269 @default.
• W2073293886 cites W2098539031 @default.
• W2073293886 cites W2100572940 @default.
• W2073293886 cites W2103863839 @default.
• W2073293886 cites W2107433166 @default.
• W2073293886 cites W2108916282 @default.
• W2073293886 cites W2113076341 @default.
• W2073293886 cites W2142313080 @default.
• W2073293886 cites W2339447116 @default.
• W2073293886 doi "https://doi.org/10.1016/j.neulet.2013.03.015" @default.
• W2073293886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3661189" @default.
• W2073293886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23523647" @default.
• W2073293886 hasPublicationYear "2013" @default.
• W2073293886 type Work @default.
• W2073293886 sameAs 2073293886 @default.
• W2073293886 citedByCount "11" @default.
• W2073293886 countsByYear W20732938862014 @default.
• W2073293886 countsByYear W20732938862015 @default.
• W2073293886 countsByYear W20732938862016 @default.
• W2073293886 countsByYear W20732938862018 @default.
• W2073293886 countsByYear W20732938862019 @default.
• W2073293886 countsByYear W20732938862020 @default.
• W2073293886 countsByYear W20732938862022 @default.
• W2073293886 crossrefType "journal-article" @default.
• W2073293886 hasAuthorship W2073293886A5000184662 @default.
• W2073293886 hasAuthorship W2073293886A5004382964 @default.
• W2073293886 hasAuthorship W2073293886A5049723883 @default.
• W2073293886 hasAuthorship W2073293886A5067322530 @default.
• W2073293886 hasAuthorship W2073293886A5091881806 @default.
• W2073293886 hasBestOaLocation W20732938862 @default.
• W2073293886 hasConcept C126322002 @default.
• W2073293886 hasConcept C134018914 @default.
• W2073293886 hasConcept C15490471 @default.
• W2073293886 hasConcept C170493617 @default.
• W2073293886 hasConcept C185592680 @default.
• W2073293886 hasConcept C2775920511 @default.
• W2073293886 hasConcept C2776885963 @default.
• W2073293886 hasConcept C2780051329 @default.
• W2073293886 hasConcept C42219234 @default.
• W2073293886 hasConcept C523546767 @default.
• W2073293886 hasConcept C54355233 @default.
• W2073293886 hasConcept C71924100 @default.
• W2073293886 hasConcept C83974742 @default.
• W2073293886 hasConcept C86803240 @default.
• W2073293886 hasConcept C98274493 @default.
• W2073293886 hasConceptScore W2073293886C126322002 @default.
• W2073293886 hasConceptScore W2073293886C134018914 @default.
• W2073293886 hasConceptScore W2073293886C15490471 @default.
• W2073293886 hasConceptScore W2073293886C170493617 @default.
• W2073293886 hasConceptScore W2073293886C185592680 @default.
• W2073293886 hasConceptScore W2073293886C2775920511 @default.
• W2073293886 hasConceptScore W2073293886C2776885963 @default.
• W2073293886 hasConceptScore W2073293886C2780051329 @default.
• W2073293886 hasConceptScore W2073293886C42219234 @default.
• W2073293886 hasConceptScore W2073293886C523546767 @default.
• W2073293886 hasConceptScore W2073293886C54355233 @default.
• W2073293886 hasConceptScore W2073293886C71924100 @default.
• W2073293886 hasConceptScore W2073293886C83974742 @default.
• W2073293886 hasConceptScore W2073293886C86803240 @default.
• W2073293886 hasConceptScore W2073293886C98274493 @default.
• W2073293886 hasLocation W20732938861 @default.
• W2073293886 hasLocation W20732938862 @default.
• W2073293886 hasLocation W20732938863 @default.
• W2073293886 hasLocation W20732938864 @default.
• W2073293886 hasOpenAccess W2073293886 @default.
• W2073293886 hasPrimaryLocation W20732938861 @default.

• next