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- W2073294426 abstract "Abstract Postmortem studies of physiologic and pathologic cardiomegaly have shown that there is an increase in the capacity of the coronary arterial tree as a result of lengthening and widening of these vessels. In adults, the coronary capillaries and arterioles do not seem to multiply and the ratio of capillaries to muscle fibers remains normal. From postmortem morphologic data it is impossible to gauge the adequacy of coronary flow with respect to the metabolic needs of the increased heart muscle mass. Based on the N 2 O method, coronary blood flow and oxygen uptake per unit mass of hypertrophied myocardium in the resting dog and man are normal except in some cases of thyrotoxicosis, severe anemia, and aortic insufficiency in which the values were above normal. In no case was the coronary flow or oxygen consumption below normal, thereby challenging the classical concept of ischemia or hypoxia as the primary cause of failure of the hypertrophied myocardium. The lack of precision of the N 2 O method was pointed out and the possibility of minor degrees of ischemia that may be critical was considered. Possible limitation in the diffusion of nutrients and metabolites (other than O 2 and CO 2 ) as the basis for metabolic derangements of the thickened myocardial fiber was emphasized. The concept of relative ischemia or hypoxia due to increased metabolic demand of the hypertrophied myocardium under resting conditions was not supported by available evidence. The importance of considering the adequacy of coronary flow during physical and mental activity of subjects with cardiomegaly was pointed out." @default.
- W2073294426 created "2016-06-24" @default.
- W2073294426 creator A5052774241 @default.
- W2073294426 date "1971-07-01" @default.
- W2073294426 modified "2023-09-23" @default.
- W2073294426 title "Myocardial blood flow and oxygen uptake in clinical and experimental cardiomegaly" @default.
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- W2073294426 doi "https://doi.org/10.1016/0002-8703(71)90168-2" @default.
- W2073294426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4253176" @default.
- W2073294426 hasPublicationYear "1971" @default.
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