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• W2073296420 abstract "Satellite phage P4 has two known options for propagation. In its lytic cycle, its regulatory functions can act in trans to alter the actions of a helper virus (P2), which then provides necessary gene products, including capsid proteins. P4 also can be propagated in the absence of a helper as a prophage, with distinct sites for integration within the Escherichia coli chromosome. We determined that a single spontaneous mutation (vir1) of phage P4 allows a third mode of propagation: as a plasmid (along with continued integration into the host chromosome). Hence, the P4 regulatory element is capable of (i) temperate; (ii) lytic, helper-dependent; and (iii) plasmid modes of development. These findings emphasize the close relationship between defective viruses and plasmids." @default.
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• W2073296420 date "1982-01-01" @default.
• W2073296420 modified "2023-09-25" @default.
• W2073296420 title "Propagation of satellite phage P4 as a plasmid." @default.
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• W2073296420 doi "https://doi.org/10.1073/pnas.79.2.515" @default.
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