Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073298048> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2073298048 endingPage "34" @default.
- W2073298048 startingPage "31" @default.
- W2073298048 abstract "Immunoglobulins in general form a substantial component of serum proteins, and play a role in homeostatic mechanisms, a first line of defense against pathogenic organisms and in immunological memory. In the secreted form, immunoglobulins represent the effector arm of the humoral immune system. However, immunoglobulins are not only secreted, but can also be expressed on the surface of a B lymphocyte (membrane immunoglobulin), and, in this physical state, most likely convey signals to steer the B cell along its differentiation pathway. A step forward in the understanding of the role of membrane immunoglobulins other than membrane IgM or IgD was achieved with two mouse lines with mutations in the epsilon heavy chain gene. In IgE(DeltaM1M2) mice serum IgE is reduced to less than 10% of normal mice, while IgE(KVKDeltatail) mice show a reduction of 50%, reflecting a serious impairment of the IgE-mediated immune response. We think that the cytoplasmic tail of IgE is involved in a signal transduction which leads to the expression of high quantities and qualities of secreted IgE immunoglobulins." @default.
- W2073298048 created "2016-06-24" @default.
- W2073298048 creator A5005096039 @default.
- W2073298048 creator A5016561809 @default.
- W2073298048 creator A5048889471 @default.
- W2073298048 creator A5060845776 @default.
- W2073298048 creator A5066986423 @default.
- W2073298048 creator A5089020336 @default.
- W2073298048 date "2001-01-01" @default.
- W2073298048 modified "2023-09-25" @default.
- W2073298048 title "The IgE Antigen Receptor: A Key Regulator for the Production of IgE Antibodies" @default.
- W2073298048 cites W2019702591 @default.
- W2073298048 cites W2020827904 @default.
- W2073298048 cites W2044692976 @default.
- W2073298048 cites W2073158216 @default.
- W2073298048 cites W2076747220 @default.
- W2073298048 doi "https://doi.org/10.1159/000053661" @default.
- W2073298048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11306919" @default.
- W2073298048 hasPublicationYear "2001" @default.
- W2073298048 type Work @default.
- W2073298048 sameAs 2073298048 @default.
- W2073298048 citedByCount "8" @default.
- W2073298048 countsByYear W20732980482013 @default.
- W2073298048 crossrefType "journal-article" @default.
- W2073298048 hasAuthorship W2073298048A5005096039 @default.
- W2073298048 hasAuthorship W2073298048A5016561809 @default.
- W2073298048 hasAuthorship W2073298048A5048889471 @default.
- W2073298048 hasAuthorship W2073298048A5060845776 @default.
- W2073298048 hasAuthorship W2073298048A5066986423 @default.
- W2073298048 hasAuthorship W2073298048A5089020336 @default.
- W2073298048 hasConcept C137756551 @default.
- W2073298048 hasConcept C141105273 @default.
- W2073298048 hasConcept C147483822 @default.
- W2073298048 hasConcept C159654299 @default.
- W2073298048 hasConcept C170493617 @default.
- W2073298048 hasConcept C203014093 @default.
- W2073298048 hasConcept C2776548049 @default.
- W2073298048 hasConcept C2778453870 @default.
- W2073298048 hasConcept C34814297 @default.
- W2073298048 hasConcept C48010095 @default.
- W2073298048 hasConcept C54355233 @default.
- W2073298048 hasConcept C86803240 @default.
- W2073298048 hasConcept C8891405 @default.
- W2073298048 hasConcept C95444343 @default.
- W2073298048 hasConceptScore W2073298048C137756551 @default.
- W2073298048 hasConceptScore W2073298048C141105273 @default.
- W2073298048 hasConceptScore W2073298048C147483822 @default.
- W2073298048 hasConceptScore W2073298048C159654299 @default.
- W2073298048 hasConceptScore W2073298048C170493617 @default.
- W2073298048 hasConceptScore W2073298048C203014093 @default.
- W2073298048 hasConceptScore W2073298048C2776548049 @default.
- W2073298048 hasConceptScore W2073298048C2778453870 @default.
- W2073298048 hasConceptScore W2073298048C34814297 @default.
- W2073298048 hasConceptScore W2073298048C48010095 @default.
- W2073298048 hasConceptScore W2073298048C54355233 @default.
- W2073298048 hasConceptScore W2073298048C86803240 @default.
- W2073298048 hasConceptScore W2073298048C8891405 @default.
- W2073298048 hasConceptScore W2073298048C95444343 @default.
- W2073298048 hasIssue "1-3" @default.
- W2073298048 hasLocation W20732980481 @default.
- W2073298048 hasLocation W20732980482 @default.
- W2073298048 hasOpenAccess W2073298048 @default.
- W2073298048 hasPrimaryLocation W20732980481 @default.
- W2073298048 hasRelatedWork W1654343738 @default.
- W2073298048 hasRelatedWork W2024252348 @default.
- W2073298048 hasRelatedWork W2033382243 @default.
- W2073298048 hasRelatedWork W2073298048 @default.
- W2073298048 hasRelatedWork W2154667422 @default.
- W2073298048 hasRelatedWork W2154760236 @default.
- W2073298048 hasRelatedWork W271486173 @default.
- W2073298048 hasRelatedWork W2916326140 @default.
- W2073298048 hasRelatedWork W4200418268 @default.
- W2073298048 hasRelatedWork W1560534955 @default.
- W2073298048 hasVolume "124" @default.
- W2073298048 isParatext "false" @default.
- W2073298048 isRetracted "false" @default.
- W2073298048 magId "2073298048" @default.
- W2073298048 workType "article" @default.