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- W2073304243 abstract "Multiple lines of research provide compelling support for an important role for central serotonergic (5-hydroxytryptamine, 5-HT) and melanocortin pathways in the regulation of food intake and body weight. In this brief review, we outline data supporting a model in which serotonergic pathways affect energy balance, in part, by converging upon central melanocortin systems to stimulate the release of the endogenous melanocortin agonist, alpha-melanocyte stimulating hormone (alpha-MSH). Further, we review the neuroanatomical mapping of a downstream target of alpha-MSH, the melanocortin 4 receptor (MC4R), in the rodent brain. We propose that downstream activation of MC4R-expressing neurons substantially contributes to serotonin's effects on energy homeostasis." @default.
- W2073304243 created "2016-06-24" @default.
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- W2073304243 date "2005-10-01" @default.
- W2073304243 modified "2023-10-13" @default.
- W2073304243 title "Serotonergic pathways converge upon central melanocortin systems to regulate energy balance" @default.
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- W2073304243 doi "https://doi.org/10.1016/j.peptides.2004.12.028" @default.
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