FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073308879> ?p ?o ?g. }

• W2073308879 endingPage "176" @default.
• W2073308879 startingPage "172" @default.
• W2073308879 abstract "When exposed to a lipid bilayer, diphtheria toxin binds to it and forms transmembrane, voltage-dependent, anion-selective channels. The mean (+/- SD) conductance of these channels in asolectin membranes is 6.2 +/- 0.7 pmho (pS) in 0.2 M NaCl and 20 +/- 2 pmho in 1.0 M NaCl. The rate of channel formation depends on the pH in the toxin-containing compartment; it is very low at pH greater than 5.0 and increases abruptly as the pH decreases from 4.9 to 4.0. Binding of toxin to the membrane is also pH dependent, being unmeasurable at pH 7 and increasing monotonically with decreasing pH. The rate of channel formation depends upon membrane potential as well; channels form only at negative potentials. These channels are permanent in the time scale of the experiments (about 1 hr). The membrane conductance caused by the channels is also voltage dependent, being constant at positive potentials and decreasing at negative potentials. Hence, the current-voltage curve is linear at positive potentials and sublinear at negative potentials. The conditions necessary for insertion of toxin into the bilayer and formation of channels are similar to those that prevail inside the lysosome. Thus, these results lend credence to the idea that toxin enters the cytoplasm from the lysosomal compartment." @default.
• W2073308879 created "2016-06-24" @default.
• W2073308879 creator A5004275469 @default.
• W2073308879 creator A5047434116 @default.
• W2073308879 creator A5056139202 @default.
• W2073308879 creator A5069751867 @default.
• W2073308879 date "1981-01-01" @default.
• W2073308879 modified "2023-09-25" @default.
• W2073308879 title "Diphtheria toxin forms transmembrane channels in planar lipid bilayers." @default.
• W2073308879 cites W1003561115 @default.
• W2073308879 cites W1496791430 @default.
• W2073308879 cites W1513505120 @default.
• W2073308879 cites W1576709265 @default.
• W2073308879 cites W1859402670 @default.
• W2073308879 cites W1967020391 @default.
• W2073308879 cites W1984277020 @default.
• W2073308879 cites W2003178300 @default.
• W2073308879 cites W2028425784 @default.
• W2073308879 cites W2046389334 @default.
• W2073308879 cites W2046967037 @default.
• W2073308879 cites W2084854410 @default.
• W2073308879 cites W2085814385 @default.
• W2073308879 cites W2095494516 @default.
• W2073308879 cites W2096490954 @default.
• W2073308879 cites W2130508879 @default.
• W2073308879 cites W2165157870 @default.
• W2073308879 cites W4247478626 @default.
• W2073308879 doi "https://doi.org/10.1073/pnas.78.1.172" @default.
• W2073308879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/319013" @default.
• W2073308879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6264431" @default.
• W2073308879 hasPublicationYear "1981" @default.
• W2073308879 type Work @default.
• W2073308879 sameAs 2073308879 @default.
• W2073308879 citedByCount "261" @default.
• W2073308879 countsByYear W20733088792012 @default.
• W2073308879 countsByYear W20733088792013 @default.
• W2073308879 countsByYear W20733088792014 @default.
• W2073308879 countsByYear W20733088792015 @default.
• W2073308879 countsByYear W20733088792016 @default.
• W2073308879 countsByYear W20733088792017 @default.
• W2073308879 countsByYear W20733088792018 @default.
• W2073308879 countsByYear W20733088792019 @default.
• W2073308879 countsByYear W20733088792021 @default.
• W2073308879 countsByYear W20733088792022 @default.
• W2073308879 countsByYear W20733088792023 @default.
• W2073308879 crossrefType "journal-article" @default.
• W2073308879 hasAuthorship W2073308879A5004275469 @default.
• W2073308879 hasAuthorship W2073308879A5047434116 @default.
• W2073308879 hasAuthorship W2073308879A5056139202 @default.
• W2073308879 hasAuthorship W2073308879A5069751867 @default.
• W2073308879 hasBestOaLocation W20733088791 @default.
• W2073308879 hasConcept C114614502 @default.
• W2073308879 hasConcept C121932024 @default.
• W2073308879 hasConcept C12554922 @default.
• W2073308879 hasConcept C170493617 @default.
• W2073308879 hasConcept C181911157 @default.
• W2073308879 hasConcept C185592680 @default.
• W2073308879 hasConcept C187632348 @default.
• W2073308879 hasConcept C192157962 @default.
• W2073308879 hasConcept C24530287 @default.
• W2073308879 hasConcept C2777367657 @default.
• W2073308879 hasConcept C33057221 @default.
• W2073308879 hasConcept C33923547 @default.
• W2073308879 hasConcept C37088560 @default.
• W2073308879 hasConcept C39944091 @default.
• W2073308879 hasConcept C41625074 @default.
• W2073308879 hasConcept C50254741 @default.
• W2073308879 hasConcept C55493867 @default.
• W2073308879 hasConcept C86803240 @default.
• W2073308879 hasConceptScore W2073308879C114614502 @default.
• W2073308879 hasConceptScore W2073308879C121932024 @default.
• W2073308879 hasConceptScore W2073308879C12554922 @default.
• W2073308879 hasConceptScore W2073308879C170493617 @default.
• W2073308879 hasConceptScore W2073308879C181911157 @default.
• W2073308879 hasConceptScore W2073308879C185592680 @default.
• W2073308879 hasConceptScore W2073308879C187632348 @default.
• W2073308879 hasConceptScore W2073308879C192157962 @default.
• W2073308879 hasConceptScore W2073308879C24530287 @default.
• W2073308879 hasConceptScore W2073308879C2777367657 @default.
• W2073308879 hasConceptScore W2073308879C33057221 @default.
• W2073308879 hasConceptScore W2073308879C33923547 @default.
• W2073308879 hasConceptScore W2073308879C37088560 @default.
• W2073308879 hasConceptScore W2073308879C39944091 @default.
• W2073308879 hasConceptScore W2073308879C41625074 @default.
• W2073308879 hasConceptScore W2073308879C50254741 @default.
• W2073308879 hasConceptScore W2073308879C55493867 @default.
• W2073308879 hasConceptScore W2073308879C86803240 @default.
• W2073308879 hasIssue "1" @default.
• W2073308879 hasLocation W20733088791 @default.
• W2073308879 hasLocation W20733088792 @default.
• W2073308879 hasLocation W20733088793 @default.
• W2073308879 hasLocation W20733088794 @default.
• W2073308879 hasLocation W20733088795 @default.
• W2073308879 hasOpenAccess W2073308879 @default.
• W2073308879 hasPrimaryLocation W20733088791 @default.
• W2073308879 hasRelatedWork W149750275 @default.
• W2073308879 hasRelatedWork W2020705112 @default.
• W2073308879 hasRelatedWork W2049173849 @default.

• next