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- W2073308911 endingPage "240" @default.
- W2073308911 startingPage "224" @default.
- W2073308911 abstract "Molecular imaging, which is the three-dimensional (3D) visualization of gene expression patterns, is indispensable for the study of the function of genes in cardiac development. The instrumentation, as well as the development of specific contrast agents for molecular imaging, has shown spectacular advances in the last decade. In this review, the spatial resolutions, contrast agents, and applications of these imaging methods in the field of cardiac embryology are discussed. Apart from 3D reconstructions from histological sections, not many of these methods have been applied in embryological research. This review shows that, for most methods, neither the spatial resolutions nor the specificity and applicability of the contrast agents are adequate for the reliable imaging of specific gene expression at the microscopic resolution required for embryological studies of small organs like the developing heart. Although a 3D reconstruction from sections will always suffer from imperfections, the resulting reconstructions meet the aim of most biological studies, especially since the original microscopic images are linked. With respect to imaging of gene expression, only histological sections and laser scanning microscopy provide the required resolution and specificity at the tissue and cellular level. Episcopic fluorescence image capturing and optical projection tomography are being used for microscopic phenotyping and lineage analysis, and both show potential for detailed molecular imaging. Other methods can be used very efficiently in rapid evaluation of biological experiments and high-throughput screens of large-scale gene expression profiling efforts when high spatial resolution is not required." @default.
- W2073308911 created "2016-06-24" @default.
- W2073308911 creator A5002005916 @default.
- W2073308911 creator A5010297463 @default.
- W2073308911 creator A5044757965 @default.
- W2073308911 creator A5046342843 @default.
- W2073308911 date "2004-09-01" @default.
- W2073308911 modified "2023-10-17" @default.
- W2073308911 title "Molecular imaging of the embryonic heart: Fables and facts on 3D imaging of gene expression patterns" @default.
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