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• W2073310947 abstract "Flavivirus infections are the most prevalent arthropod-borne infections world wide, often causing severe disease especially among children, the elderly, and the immunocompromised. In the absence of effective antiviral treatment, prevention through vaccination would greatly reduce morbidity and mortality associated with flavivirus infections. Despite the success of the empirically developed vaccines against yellow fever virus, Japanese encephalitis virus and tick-borne encephalitis virus, there is an increasing need for a more rational design and development of safe and effective vaccines. Several bioinformatic tools are available to support such rational vaccine design. In doing so, several parameters have to be taken into account, such as safety for the target population, overall immunogenicity of the candidate vaccine, and efficacy and longevity of the immune responses triggered. Examples of how bio-informatics is applied to assist in the rational design and improvements of vaccines, particularly flavivirus vaccines, are presented and discussed." @default.
• W2073310947 created "2016-06-24" @default.
• W2073310947 creator A5003462353 @default.
• W2073310947 creator A5012442242 @default.
• W2073310947 creator A5016429671 @default.
• W2073310947 date "2010-01-01" @default.
• W2073310947 modified "2023-09-29" @default.
• W2073310947 title "Bioinformatics in New Generation Flavivirus Vaccines" @default.
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