FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073313025> ?p ?o ?g. }

• W2073313025 endingPage "85" @default.
• W2073313025 startingPage "73" @default.
• W2073313025 abstract "The ventromedial prefrontal cortex (vmPFC) is extremely sensitive to a variety of stressful situations and threatening events, and has been suggested to be an associative cortical brain system processing the integration of anxiety-related cognitive, affective and motivated behavior in rodents, primates and humans. In addition, recent evidence suggests that (a) anxiety-related affective processing appears to be lateralized to the right hemisphere vmPFC; and (b) there appears to be functional heterogeneity within the rodent vmPFC. The present study evaluated the possibility that distinct sub-areas of the right hemisphere ventral PFC might differentially influence anxiety-like defensive responding in two different predator stress situations following transient inactivation of the ventromedial orbital (vMO) or infralimbic (IL) vmPFC in CD-1 mice. In week 1, IL vmPFC lidocaine infusions reduced anxiety-like defensive responding in mice (enhanced approach and contact) confronted with a hand-held anesthetized rat stimulus in the mouse defense test battery (vMO inactivation exerted minimal effects). In week 2, vMO lidocaine infusions enhanced anxiety-like defensive responding (enhanced avoidance and protected risk assessment) toward a barricaded live rat in the rat exposure test (IL inactivation exerted minimal effects). Although it is unclear whether week 1 mouse defense test battery testing influenced week 2 rat exposure test results, these preliminary data suggest functional differences within the mouse right hemisphere ventral PFC related to cautious evaluation of predator threat. Given the dense unilateral reciprocal connectivity between the IL and vMO subregions of the PFC, both associative ventromedial cortical areas may exert complimentary yet dissociable roles in the processing of threat stimuli. This suggests that while the IL vmPFC may mediate cautious evaluation of threat situations (risk assessment), the vMO PFC may inhibit prepotent avoidance responses to facilitate such IL-mediated adaptive behavioral responses." @default.
• W2073313025 created "2016-06-24" @default.
• W2073313025 creator A5049002822 @default.
• W2073313025 creator A5067568438 @default.
• W2073313025 creator A5079245844 @default.
• W2073313025 creator A5082955993 @default.
• W2073313025 date "2004-09-01" @default.
• W2073313025 modified "2023-10-14" @default.
• W2073313025 title "Differential effects of infralimbic vs. ventromedial orbital PFC lidocaine infusions in CD-1 mice on defensive responding in the mouse defense test battery and rat exposure test" @default.
• W2073313025 cites W1482139424 @default.
• W2073313025 cites W1499836032 @default.
• W2073313025 cites W1541410122 @default.
• W2073313025 cites W1552042987 @default.
• W2073313025 cites W1572495684 @default.
• W2073313025 cites W1585501195 @default.
• W2073313025 cites W1762920573 @default.
• W2073313025 cites W1867720884 @default.
• W2073313025 cites W1948130162 @default.
• W2073313025 cites W1964779920 @default.
• W2073313025 cites W1967827729 @default.
• W2073313025 cites W1972685191 @default.
• W2073313025 cites W1975190631 @default.
• W2073313025 cites W1975908397 @default.
• W2073313025 cites W1975919142 @default.
• W2073313025 cites W1978465899 @default.
• W2073313025 cites W1979166255 @default.
• W2073313025 cites W1979300762 @default.
• W2073313025 cites W1979487363 @default.
• W2073313025 cites W1981166601 @default.
• W2073313025 cites W1983090694 @default.
• W2073313025 cites W1985833959 @default.
• W2073313025 cites W1989045560 @default.
• W2073313025 cites W1989084087 @default.
• W2073313025 cites W1990694352 @default.
• W2073313025 cites W1991911963 @default.
• W2073313025 cites W1991990729 @default.
• W2073313025 cites W1993239654 @default.
• W2073313025 cites W1993634951 @default.
• W2073313025 cites W1997782822 @default.
• W2073313025 cites W1998604513 @default.
• W2073313025 cites W2003250265 @default.
• W2073313025 cites W2003261003 @default.
• W2073313025 cites W2006041248 @default.
• W2073313025 cites W2006221927 @default.
• W2073313025 cites W2008860212 @default.
• W2073313025 cites W2010570008 @default.
• W2073313025 cites W2014304586 @default.
• W2073313025 cites W2015443956 @default.
• W2073313025 cites W2015938627 @default.
• W2073313025 cites W2027478606 @default.
• W2073313025 cites W2030246136 @default.
• W2073313025 cites W2031636627 @default.
• W2073313025 cites W2033284293 @default.
• W2073313025 cites W2035241965 @default.
• W2073313025 cites W2036642338 @default.
• W2073313025 cites W2036961358 @default.
• W2073313025 cites W2037277347 @default.
• W2073313025 cites W2038933762 @default.
• W2073313025 cites W2040646874 @default.
• W2073313025 cites W2041000222 @default.
• W2073313025 cites W2042447056 @default.
• W2073313025 cites W2048859902 @default.
• W2073313025 cites W2050950253 @default.
• W2073313025 cites W2052729847 @default.
• W2073313025 cites W2055117351 @default.
• W2073313025 cites W2058982402 @default.
• W2073313025 cites W2063122426 @default.
• W2073313025 cites W2064636484 @default.
• W2073313025 cites W2064674087 @default.
• W2073313025 cites W2069281002 @default.
• W2073313025 cites W2075565974 @default.
• W2073313025 cites W2076702669 @default.
• W2073313025 cites W2080046881 @default.
• W2073313025 cites W2081642963 @default.
• W2073313025 cites W2082887417 @default.
• W2073313025 cites W2085924433 @default.
• W2073313025 cites W2087180408 @default.
• W2073313025 cites W2090685136 @default.
• W2073313025 cites W2091095827 @default.
• W2073313025 cites W2094408618 @default.
• W2073313025 cites W2096127917 @default.
• W2073313025 cites W2105133778 @default.
• W2073313025 cites W2110338437 @default.
• W2073313025 cites W2111225560 @default.
• W2073313025 cites W2114262893 @default.
• W2073313025 cites W2116807236 @default.
• W2073313025 cites W2116813115 @default.
• W2073313025 cites W2119185387 @default.
• W2073313025 cites W2119392695 @default.
• W2073313025 cites W2120520226 @default.
• W2073313025 cites W2122297603 @default.
• W2073313025 cites W2124833043 @default.
• W2073313025 cites W2126380345 @default.
• W2073313025 cites W2128192350 @default.
• W2073313025 cites W2129028793 @default.
• W2073313025 cites W2130822068 @default.
• W2073313025 cites W2130838343 @default.
• W2073313025 cites W2134806750 @default.

• next