FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073330897> ?p ?o ?g. }

• W2073330897 endingPage "320" @default.
• W2073330897 startingPage "313" @default.
• W2073330897 abstract "The glial intermediate filament protein (GFAP) gene is not normally expressed by retinal Müller cells but it is transcriptionally activated following photoreceptor degeneration. In the present study, we have examined the relationship between progressive photoreceptor loss and changes in GFAP gene activity in Müller cells. In albino mice with light-induced photoreceptor degeneration, GFAP level was strongly elevated after 2 weeks. GFAP level remained high even after 3 months in light. In situ hybridization studies showed that GFAP transcripts were quite sparse in the first week but increased dramatically after 2 weeks of light exposure. After 4 weeks in constant light, however, little GFAP mRNA was detected in Müller cells. RNA blotting also showed that there was an ∼20-fold increase in GFAP mRNA content at 2 weeks; but at 4 weeks, the RNA content fell to about four-fold higher than the basal level. These results show that GFAP level remains high long after its synthesis, probably as a consequence of low GFAP turnover in the Müller cell cytoskeleton, while GFAP mRNA level rises and declines rapidly due to transient activation of the GFAP gene in Müller cells." @default.
• W2073330897 created "2016-06-24" @default.
• W2073330897 creator A5019388522 @default.
• W2073330897 creator A5030639623 @default.
• W2073330897 date "1995-04-01" @default.
• W2073330897 modified "2023-10-18" @default.
• W2073330897 title "Transient Induction of the Glial Intermediate Filament Protein Gene in Müller Cells in the Mouse Retina" @default.
• W2073330897 cites W1505645702 @default.
• W2073330897 cites W1552427867 @default.
• W2073330897 cites W1577079088 @default.
• W2073330897 cites W1762551333 @default.
• W2073330897 cites W1859694492 @default.
• W2073330897 cites W1904875888 @default.
• W2073330897 cites W1965718695 @default.
• W2073330897 cites W1968074776 @default.
• W2073330897 cites W1970306637 @default.
• W2073330897 cites W1982387821 @default.
• W2073330897 cites W1982741576 @default.
• W2073330897 cites W1982915032 @default.
• W2073330897 cites W1988184119 @default.
• W2073330897 cites W1994626566 @default.
• W2073330897 cites W1997136014 @default.
• W2073330897 cites W2005021221 @default.
• W2073330897 cites W2010110359 @default.
• W2073330897 cites W2014174952 @default.
• W2073330897 cites W2019956654 @default.
• W2073330897 cites W2023114874 @default.
• W2073330897 cites W2035185214 @default.
• W2073330897 cites W2049161531 @default.
• W2073330897 cites W2056328342 @default.
• W2073330897 cites W2064368446 @default.
• W2073330897 cites W2072812579 @default.
• W2073330897 cites W2086038185 @default.
• W2073330897 cites W2089390647 @default.
• W2073330897 cites W2089549370 @default.
• W2073330897 cites W2091632562 @default.
• W2073330897 cites W2114115955 @default.
• W2073330897 cites W2149802624 @default.
• W2073330897 doi "https://doi.org/10.1089/dna.1995.14.313" @default.
• W2073330897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7710688" @default.
• W2073330897 hasPublicationYear "1995" @default.
• W2073330897 type Work @default.
• W2073330897 sameAs 2073330897 @default.
• W2073330897 citedByCount "24" @default.
• W2073330897 countsByYear W20733308972014 @default.
• W2073330897 countsByYear W20733308972015 @default.
• W2073330897 countsByYear W20733308972016 @default.
• W2073330897 countsByYear W20733308972017 @default.
• W2073330897 countsByYear W20733308972018 @default.
• W2073330897 countsByYear W20733308972023 @default.
• W2073330897 crossrefType "journal-article" @default.
• W2073330897 hasAuthorship W2073330897A5019388522 @default.
• W2073330897 hasAuthorship W2073330897A5030639623 @default.
• W2073330897 hasConcept C104317684 @default.
• W2073330897 hasConcept C105580179 @default.
• W2073330897 hasConcept C142669718 @default.
• W2073330897 hasConcept C1491633281 @default.
• W2073330897 hasConcept C150194340 @default.
• W2073330897 hasConcept C153911025 @default.
• W2073330897 hasConcept C159431405 @default.
• W2073330897 hasConcept C169760540 @default.
• W2073330897 hasConcept C203014093 @default.
• W2073330897 hasConcept C204232928 @default.
• W2073330897 hasConcept C2777093970 @default.
• W2073330897 hasConcept C2780495277 @default.
• W2073330897 hasConcept C2780827179 @default.
• W2073330897 hasConcept C2781040256 @default.
• W2073330897 hasConcept C55493867 @default.
• W2073330897 hasConcept C78383274 @default.
• W2073330897 hasConcept C81439078 @default.
• W2073330897 hasConcept C86803240 @default.
• W2073330897 hasConcept C95444343 @default.
• W2073330897 hasConceptScore W2073330897C104317684 @default.
• W2073330897 hasConceptScore W2073330897C105580179 @default.
• W2073330897 hasConceptScore W2073330897C142669718 @default.
• W2073330897 hasConceptScore W2073330897C1491633281 @default.
• W2073330897 hasConceptScore W2073330897C150194340 @default.
• W2073330897 hasConceptScore W2073330897C153911025 @default.
• W2073330897 hasConceptScore W2073330897C159431405 @default.
• W2073330897 hasConceptScore W2073330897C169760540 @default.
• W2073330897 hasConceptScore W2073330897C203014093 @default.
• W2073330897 hasConceptScore W2073330897C204232928 @default.
• W2073330897 hasConceptScore W2073330897C2777093970 @default.
• W2073330897 hasConceptScore W2073330897C2780495277 @default.
• W2073330897 hasConceptScore W2073330897C2780827179 @default.
• W2073330897 hasConceptScore W2073330897C2781040256 @default.
• W2073330897 hasConceptScore W2073330897C55493867 @default.
• W2073330897 hasConceptScore W2073330897C78383274 @default.
• W2073330897 hasConceptScore W2073330897C81439078 @default.
• W2073330897 hasConceptScore W2073330897C86803240 @default.
• W2073330897 hasConceptScore W2073330897C95444343 @default.
• W2073330897 hasIssue "4" @default.
• W2073330897 hasLocation W20733308971 @default.
• W2073330897 hasLocation W20733308972 @default.
• W2073330897 hasOpenAccess W2073330897 @default.
• W2073330897 hasPrimaryLocation W20733308971 @default.
• W2073330897 hasRelatedWork W1551925364 @default.
• W2073330897 hasRelatedWork W1965465274 @default.

• next