FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073332085> ?p ?o ?g. }

• W2073332085 endingPage "127" @default.
• W2073332085 startingPage "121" @default.
• W2073332085 abstract "Objectives: There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 inhibitors. Although the benefits of COX-2 inhibition may eventually outweigh the associated cardiovascular risks, there are a number of alternative targets for inhibiting the formation of PGE2 in human tumors that may prove less harmful to the patient. This study aimed at analyzing the expression of various proteins involved in the generation of PGE2 in human pancreatic cancers. Methods and Results: Real-time polymerase chain reaction and Western blot analyses demonstrated overexpression of cytoplasmic phospholipase A2, COX-2, cytoplasmic prostaglandin E synthase, and microsomal prostaglandin E synthases 1 and 2 in most human pancreatic cancers when compared with matched normal pancreas. Immunohistochemistry revealed expression of these proteins predominantly by pancreatic cancer cells. Variable expression of these proteins was also confirmed in several human pancreatic cancer cell lines. Conclusions: Our studies demonstrated for the first time that various proteins involved in the generation of PGE2 are overexpressed in human pancreatic cancers. These proteins may represent potentially novel targets for the therapy of pancreatic cancers." @default.
• W2073332085 created "2016-06-24" @default.
• W2073332085 creator A5008501152 @default.
• W2073332085 creator A5008524910 @default.
• W2073332085 creator A5019576697 @default.
• W2073332085 creator A5037516913 @default.
• W2073332085 creator A5042354527 @default.
• W2073332085 creator A5047089607 @default.
• W2073332085 creator A5055862375 @default.
• W2073332085 creator A5067785220 @default.
• W2073332085 creator A5083578717 @default.
• W2073332085 date "2008-08-01" @default.
• W2073332085 modified "2023-10-16" @default.
• W2073332085 title "Expression Analysis of the Prostaglandin E2 Production Pathway in Human Pancreatic Cancers" @default.
• W2073332085 cites W1896839509 @default.
• W2073332085 cites W1965734230 @default.
• W2073332085 cites W1967641836 @default.
• W2073332085 cites W1978118982 @default.
• W2073332085 cites W1981017032 @default.
• W2073332085 cites W1981493281 @default.
• W2073332085 cites W1989696800 @default.
• W2073332085 cites W1998855245 @default.
• W2073332085 cites W1999401349 @default.
• W2073332085 cites W2017816682 @default.
• W2073332085 cites W2025970479 @default.
• W2073332085 cites W2032607036 @default.
• W2073332085 cites W2034440071 @default.
• W2073332085 cites W2044058423 @default.
• W2073332085 cites W2056150927 @default.
• W2073332085 cites W2060800275 @default.
• W2073332085 cites W2062606721 @default.
• W2073332085 cites W2084015052 @default.
• W2073332085 cites W2096874183 @default.
• W2073332085 cites W2101249156 @default.
• W2073332085 cites W2105581153 @default.
• W2073332085 cites W2119016440 @default.
• W2073332085 cites W2127607312 @default.
• W2073332085 cites W2167029659 @default.
• W2073332085 cites W58478469 @default.
• W2073332085 doi "https://doi.org/10.1097/mpa.0b013e31816618ba" @default.
• W2073332085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18665070" @default.
• W2073332085 hasPublicationYear "2008" @default.
• W2073332085 type Work @default.
• W2073332085 sameAs 2073332085 @default.
• W2073332085 citedByCount "40" @default.
• W2073332085 countsByYear W20733320852012 @default.
• W2073332085 countsByYear W20733320852013 @default.
• W2073332085 countsByYear W20733320852014 @default.
• W2073332085 countsByYear W20733320852015 @default.
• W2073332085 countsByYear W20733320852016 @default.
• W2073332085 countsByYear W20733320852017 @default.
• W2073332085 countsByYear W20733320852018 @default.
• W2073332085 countsByYear W20733320852019 @default.
• W2073332085 countsByYear W20733320852020 @default.
• W2073332085 countsByYear W20733320852021 @default.
• W2073332085 countsByYear W20733320852022 @default.
• W2073332085 countsByYear W20733320852023 @default.
• W2073332085 crossrefType "journal-article" @default.
• W2073332085 hasAuthorship W2073332085A5008501152 @default.
• W2073332085 hasAuthorship W2073332085A5008524910 @default.
• W2073332085 hasAuthorship W2073332085A5019576697 @default.
• W2073332085 hasAuthorship W2073332085A5037516913 @default.
• W2073332085 hasAuthorship W2073332085A5042354527 @default.
• W2073332085 hasAuthorship W2073332085A5047089607 @default.
• W2073332085 hasAuthorship W2073332085A5055862375 @default.
• W2073332085 hasAuthorship W2073332085A5067785220 @default.
• W2073332085 hasAuthorship W2073332085A5083578717 @default.
• W2073332085 hasConcept C104317684 @default.
• W2073332085 hasConcept C121608353 @default.
• W2073332085 hasConcept C126322002 @default.
• W2073332085 hasConcept C134018914 @default.
• W2073332085 hasConcept C181199279 @default.
• W2073332085 hasConcept C204232928 @default.
• W2073332085 hasConcept C2776415932 @default.
• W2073332085 hasConcept C2776551241 @default.
• W2073332085 hasConcept C2777956040 @default.
• W2073332085 hasConcept C2778764654 @default.
• W2073332085 hasConcept C2779689624 @default.
• W2073332085 hasConcept C2780210213 @default.
• W2073332085 hasConcept C2780664492 @default.
• W2073332085 hasConcept C502942594 @default.
• W2073332085 hasConcept C55493867 @default.
• W2073332085 hasConcept C555283112 @default.
• W2073332085 hasConcept C71924100 @default.
• W2073332085 hasConcept C86803240 @default.
• W2073332085 hasConceptScore W2073332085C104317684 @default.
• W2073332085 hasConceptScore W2073332085C121608353 @default.
• W2073332085 hasConceptScore W2073332085C126322002 @default.
• W2073332085 hasConceptScore W2073332085C134018914 @default.
• W2073332085 hasConceptScore W2073332085C181199279 @default.
• W2073332085 hasConceptScore W2073332085C204232928 @default.
• W2073332085 hasConceptScore W2073332085C2776415932 @default.
• W2073332085 hasConceptScore W2073332085C2776551241 @default.
• W2073332085 hasConceptScore W2073332085C2777956040 @default.
• W2073332085 hasConceptScore W2073332085C2778764654 @default.
• W2073332085 hasConceptScore W2073332085C2779689624 @default.
• W2073332085 hasConceptScore W2073332085C2780210213 @default.
• W2073332085 hasConceptScore W2073332085C2780664492 @default.

• next