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- W2073341228 abstract "Age-related loss of muscle mass and function, termed sarcopenia, is a catastrophic process, which impacts severely on quality of life of older people. The mechanisms underlying sarcopenia are unclear and the development of optimal therapeutic interventions remains elusive. Impaired regenerative capacity, attenuated ability to respond to stress, elevated reactive oxygen species production and low-grade systemic inflammation are all key contributors to sarcopenia. Pharmacological intervention using compounds such as 17AAG, SS-31 and Bimagrumab or naturally occurring polyphenols to target specific pathways show potential benefit to combat sarcopenia although further research is required, particularly to identify the mechanisms by which muscle fibres are completely lost with increasing age." @default.
- W2073341228 created "2016-06-24" @default.
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- W2073341228 date "2014-06-01" @default.
- W2073341228 modified "2023-09-26" @default.
- W2073341228 title "Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention" @default.
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- W2073341228 doi "https://doi.org/10.1016/j.coph.2014.05.005" @default.
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