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• W2073345232 abstract "Several synthetic 2'-O-methyl-RNA oligomers and their derivatives have been evaluated for inhibitory effect against HIV-induced cytopathic effect and expression of the virus specific antigen in cultured MT-4 cells. In this study, oligo(2'-O-methyl)ribonucleoside phosphorothioates showed a potent inhibitory activity with size dependency (25-mer showed it at 1 microM), but by contrast both 2'-O-methylribo- and deoxy-oligomers with normal phosphate linkages failed to inhibit. However, it should be noted that the patched oligo(2'-O-methyl)ribonucleotide (20-mer), in which five linkages at 5'- and three linkages at 3'-ends of normal phosphates were replaced with thiophosphates, has recovered the substantial inhibitory effect. These results show that the size of oligomer and phosphorothioate linkages, probably resistant to exolytic nucleases, are essential for exhibiting antiviral activity." @default.
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• W2073345232 date "1989-01-01" @default.
• W2073345232 modified "2023-10-04" @default.
• W2073345232 title "Inhibition of human immunodeficiency virus (HIV-1) replication by synthetic oligo-RNA derivatives" @default.
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• W2073345232 doi "https://doi.org/10.1093/nar/17.1.239" @default.
• W2073345232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/331548" @default.
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