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- W2073349063 abstract "Using a fluorescent avidin-biotin technique, we have immunolocalized the GABA synthesizing enzyme, glutamate decarboxylase, in postnatal developing and adult rat organs of Corti. At birth, the glutamate decarboxylase-like immunoreactivity is already present in the basal turn below the inner hair cells, i.e. within lateral olivocochlear efferent fibers of the inner spiral bundle. In the apical turn, the inner spiral bundle displays an immunoreactivity as early as postnatal day 3. Only the outer hair cells of the upper second turn and apex receive fibers immunostained for glutamate decarboxylase that most probably belong to the medial olivocochlear efferent innervation. They first appear at this level at postnatal day 15. Within these two regions of the organ of Corti, the glutamate decarboxylase-like immunoreactivity reaches an adult-like pattern at postnatal days 17-18. These results strengthen the hypothesis that GABA is a putative neurotransmitter that could be used by subpopulations of the two olivocochlear innervations. They also suggest that GABA either plays a neurotrophic function or participates in the regulation of the first cochlear potentials at the level of lateral efferent synapses." @default.
- W2073349063 created "2016-06-24" @default.
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- W2073349063 date "1990-01-01" @default.
- W2073349063 modified "2023-10-02" @default.
- W2073349063 title "Immunocytochemical detection of glutamate decarboxylase in the postnatal developing rat organ of corti" @default.
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- W2073349063 doi "https://doi.org/10.1016/0736-5748(90)90053-5" @default.
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