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• W2073359488 abstract "In normal controls, female gender and low-normal haematocrit levels have pro-coagulant effects. We utilized Thromboelastography® (TEG) to assess, I) effects of gender on coagulation, and II) relationship with standard coagulation tests (SCT). In contrast to SCT, TEG® measures clot formation, strength, and lysis in whole blood under low shear forces resembling physiologic venous flow. TEG parameters usually measured are R time, K time, Angle, and MA or Maximum Amplitude. ”Shorter R and K time, and larger Angle and MA are indicative of accelerated coagulation”. [Reference values for R=2-8 min, K=1-3 min, Angle=55-78°, MA=51-69 mm]. Retrospectively, records of 146 adult CABG surgery patients were reviewed. Baseline preoperative kaolin heparinase TEG® parameters R, K, Angle, and MA were recorded. Adults with pre-existing coagulation abnormalities, liver failure, or renal failure were excluded. Preoperatively, there was no gender differences in SCT i.e. [platelet count (P=0.39), PT (P=0.32), PTT (P=0.35)] and baseline creatinine (P=0.15). But females were older (P=0.001), had lower BSA (P<0.0001) and lower preoperative haematocrit (P=0.0001). Females demonstrated accelerated coagulation status compared to men, shorter R [7.67±1.77 vs. 6.65±1.69 min (P=0.003)], shorter K [1.94±0.59 vs. 1.59±0.45 min (P=0.002)], larger Angle [63.61±6.33 vs. 67.74±5.90 ° (P=0.001) and larger MA [63.13±6.33 vs. 67.74±67.63 mm (P=0.0002). Gender specific TEG® data was further analysed by percentiles into 4 sub-groups [≤P25, P25-P50, P50-75, and ≥P75]. Compared to males, fewer females had R values ≥75 (86.87% vs. 61.11%) [P=0.0067], more females had K values ≤P25 (22.77% vs. 50.0%) [P=0.0038], Angle values ≥P75 (5.88% vs. 22.22%) [P=0.0138], and MA values ≥P75 (52.94% vs. 86.11%) [P=0.0045]. Relationship of individual TEG parameters with SCT: a) TEG R, directly to pre-op PTT (P=0.04)] and no relation with pre-op PT, platelet count and haematocrit (P>0.05). b) TEG K, inversely to pre-op platelet count (P=0.03)], directly to haematocrit (P<0.0001) and no relation with pre-op PT and PTT (P>0.05). c) TEG Angle, inversely to pre-op haematocrit (P<0.0001)], no relation with Pre-op PT, PTT, and platelet count (P>0.05). d) TEG MA, directly to pre-op platelet count (P=0.003), inversely to pre-op haematocrit (P<0.0001) and no relation with PT and PTT (P>0.05). Despite no gender differences in baseline SCT in adult CABG surgery patients, TEG® demonstrated female gender and low-normal haematocrit were associated with accelerated coagulation." @default.
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• W2073359488 date "2011-06-01" @default.
• W2073359488 modified "2023-09-26" @default.
• W2073359488 title "P-26 Does gender influence pre-operative coagulation status in adults undergoing coronary artery bypass graft surgery?" @default.
• W2073359488 cites W2058988939 @default.
• W2073359488 cites W2122473579 @default.
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• W2073359488 doi "https://doi.org/10.1053/j.jvca.2011.03.119" @default.
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