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• W2073366872 abstract "Francisella tularensis, which is a Gram negative bacterium that causes tularemia, has been classified by the Center for Disease Control and Prevention (CDC) as a category A bioweapon. The development of vaccines, immunotherapeutics, and diagnostics for F. tularensis requires a detailed knowledge of the saccharide structures that can be recognized by protective antibodies. We have synthesized the inner core region of the lipopolysaccharide (LPS) of F. tularensis to probe antigenic responses elicited by a live and subunit vaccine. The successful preparation of the target compound relied on the use of a disaccharide which was modified by the orthogonal protecting groups diethylisopropylsilyl (DEIPS), 2-naphthylmethyl (Nap), allyl ether (All), and levulinoyl (Lev) ester. The ability to remove the protecting groups in different orders made it possible to establish the optimal glycosylations sequence to prepare a highly crowded 1,2,3-cis configured branching point. A variety of different methods were exploited to control anomeric selectivities of the glycosylations. A comparison of the 1H NMR spectra of isolated material and the synthetic derivative confirmed the reported structural assignment of the inner core oligosaccharide of F. tularensis. The observation that immunizations with LPS lead to antibody responses to the inner core saccharides provides an impetus to further explore this compound as a vaccine candidate." @default.
• W2073366872 created "2016-06-24" @default.
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• W2073366872 date "2012-08-16" @default.
• W2073366872 modified "2023-10-08" @default.
• W2073366872 title "Chemical Synthesis and Immunological Evaluation of the Inner Core Oligosaccharide of Francisella tularensis" @default.
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• W2073366872 doi "https://doi.org/10.1021/ja306274v" @default.
• W2073366872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3458509" @default.
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