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- W2073375166 endingPage "481" @default.
- W2073375166 startingPage "472" @default.
- W2073375166 abstract "Adhesion-mediated signaling provides cells with information about multiple parameters of their microenvironment, including mechanical characteristics. Often, such signaling is based on a unique feature of adhesion structures: their ability to grow and strengthen when force is applied to them, either from within the cell or from the outside. Such adhesion reinforcement is characteristic of integrin-mediated cell–matrix adhesions, but may also operate in other types of adhesion structures. Though the amount of knowledge about adhesion-mediated signaling is growing rapidly, the mechanisms underlying force-dependent regulation of junction assembly are largely unknown. Experiments have been carried out that have started to uncover the major signaling pathways involved in the response of adhesion sites to force. Theoretical models have also been used to address the physical mechanisms underlying adhesion-mediated mechanosensing." @default.
- W2073375166 created "2016-06-24" @default.
- W2073375166 creator A5046264807 @default.
- W2073375166 creator A5062465955 @default.
- W2073375166 creator A5067297874 @default.
- W2073375166 date "2006-10-01" @default.
- W2073375166 modified "2023-10-11" @default.
- W2073375166 title "Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize" @default.
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