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- W2073384988 endingPage "59" @default.
- W2073384988 startingPage "59" @default.
- W2073384988 abstract "Cell signaling is a very complex network of biochemical reactions triggered by a huge number of stimuli coming from the external medium. The function of any single signaling component depends not only on its own structure but also on its connections with other biomolecules. During prokaryotic-eukaryotic transition, the rearrangement of cell organization in terms of diffusional compartmentalization exerts a deep change in cell signaling functional potentiality. In this review I briefly introduce an intriguing ancient relationship between pathways involved in cell responses to chemical agonists (growth factors, nutrients, hormones) as well as to mechanical forces (stretch, osmotic changes). Some biomolecules (ion channels and enzymes) act as hubs, thanks to their ability to be directly or indirectly chemically/mechanically co-regulated. In particular calcium signaling machinery and arachidonic acid metabolism are very ancient networks, already present before eukaryotic appearance. A number of molecular hubs, including phospholipase A2 and some calcium channels, appear tightly interconnected in a cross regulation leading to the cellular response to chemical and mechanical stimulations." @default.
- W2073384988 created "2016-06-24" @default.
- W2073384988 creator A5059836069 @default.
- W2073384988 date "2011-01-01" @default.
- W2073384988 modified "2023-10-06" @default.
- W2073384988 title "Shuffling the cards in signal transduction: Calcium, arachidonic acid and mechanosensitivity" @default.
- W2073384988 cites W10010044 @default.
- W2073384988 cites W1484772899 @default.
- W2073384988 cites W1511784042 @default.
- W2073384988 cites W1525467358 @default.
- W2073384988 cites W1537970310 @default.
- W2073384988 cites W1599277155 @default.
- W2073384988 cites W1707717597 @default.
- W2073384988 cites W1856590789 @default.
- W2073384988 cites W1917990717 @default.
- W2073384988 cites W1940716720 @default.
- W2073384988 cites W1963909152 @default.
- W2073384988 cites W1964567018 @default.
- W2073384988 cites W1966556984 @default.
- W2073384988 cites W1966740493 @default.
- W2073384988 cites W1973578772 @default.
- W2073384988 cites W1982950893 @default.
- W2073384988 cites W1990529300 @default.
- W2073384988 cites W1992601827 @default.
- W2073384988 cites W1993562651 @default.
- W2073384988 cites W1996789762 @default.
- W2073384988 cites W1998390454 @default.
- W2073384988 cites W1999374220 @default.
- W2073384988 cites W2001738143 @default.
- W2073384988 cites W2002966495 @default.
- W2073384988 cites W2014981955 @default.
- W2073384988 cites W2015592781 @default.
- W2073384988 cites W2018411282 @default.
- W2073384988 cites W2019819813 @default.
- W2073384988 cites W2021140520 @default.
- W2073384988 cites W2023966975 @default.
- W2073384988 cites W2029784048 @default.
- W2073384988 cites W2030396326 @default.
- W2073384988 cites W2031705216 @default.
- W2073384988 cites W2037864200 @default.
- W2073384988 cites W2040753593 @default.
- W2073384988 cites W2048791682 @default.
- W2073384988 cites W2052072889 @default.
- W2073384988 cites W2055870673 @default.
- W2073384988 cites W2058051043 @default.
- W2073384988 cites W2062730575 @default.
- W2073384988 cites W2069156601 @default.
- W2073384988 cites W2074954129 @default.
- W2073384988 cites W2080868953 @default.
- W2073384988 cites W2083517980 @default.
- W2073384988 cites W2083681924 @default.
- W2073384988 cites W2084344997 @default.
- W2073384988 cites W2085242926 @default.
- W2073384988 cites W2086264391 @default.
- W2073384988 cites W2087756673 @default.
- W2073384988 cites W2087828263 @default.
- W2073384988 cites W2090621246 @default.
- W2073384988 cites W2093977379 @default.
- W2073384988 cites W2100733539 @default.
- W2073384988 cites W2101860500 @default.
- W2073384988 cites W2102204826 @default.
- W2073384988 cites W2102305820 @default.
- W2073384988 cites W2104764277 @default.
- W2073384988 cites W2105431222 @default.
- W2073384988 cites W2116655439 @default.
- W2073384988 cites W2118595167 @default.
- W2073384988 cites W2120919525 @default.
- W2073384988 cites W2121167940 @default.
- W2073384988 cites W2132305492 @default.
- W2073384988 cites W2135353780 @default.
- W2073384988 cites W2135422266 @default.
- W2073384988 cites W2136605787 @default.
- W2073384988 cites W2139027761 @default.
- W2073384988 cites W2141818631 @default.
- W2073384988 cites W2145691944 @default.
- W2073384988 cites W2146241742 @default.
- W2073384988 cites W2149429155 @default.
- W2073384988 cites W2150942343 @default.
- W2073384988 cites W2152658124 @default.
- W2073384988 cites W2155469071 @default.
- W2073384988 cites W2156831614 @default.
- W2073384988 cites W2157547888 @default.
- W2073384988 cites W2158743966 @default.
- W2073384988 cites W2159760243 @default.
- W2073384988 cites W21624655 @default.
- W2073384988 cites W2163211533 @default.
- W2073384988 cites W2340906142 @default.
- W2073384988 cites W2409325295 @default.
- W2073384988 cites W3023991356 @default.
- W2073384988 cites W4233595534 @default.
- W2073384988 cites W4255760236 @default.
- W2073384988 doi "https://doi.org/10.4331/wjbc.v2.i4.59" @default.
- W2073384988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3083947" @default.
- W2073384988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21537474" @default.
- W2073384988 hasPublicationYear "2011" @default.
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