Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073399032> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2073399032 abstract "The bactericidal activity of 0.5% bupivacaine with preservatives at body temperature and at room temperature is not known. We studied the bactericidal activity of 0.5% bupivacaine with 0.08% methyl para-oxybenzoate and 0.02% propyl para-aminobenzoate as preservatives and of the preservatives alone at 37 degrees C and at room temperature on two strains of methicillin-resistant Staphylococcus aureus, two strains of methicillin-susceptible S. aureus, and one strain each of Staphylococcus epidermidis and Escherichia coli.The pathogen was exposed to 0.5% bupivacaine with preservatives or to the preservatives alone for 1, 3, 6, 12, and 24 hours at 37 degrees C and at room temperature. The inocula from these suspensions were cultured for 48 hours at 37 degrees C after the antimicrobial activity of bupivacaine was inactivated by 1:1,000 dilution with physiological saline.The 1- through 12-hour exposures of four strains of S. aureus to 0.5% bupivacaine with preservatives at room temperature reduced the mean colony count by 24.2%, 49.2%, 71.3%, and 89.6%, respectively, and the exposure at 37 degrees C reduced the count by 74.1%, 95.2%, 99.9%, and 99.8%, respectively. The differences for 1- through 12-hour exposures were significant (P < .001). The percentage kill in the strains of E. coli and S. epidermidis was significantly higher than that in the strains of S. aureus at all exposure times at room temperature (E. coli, P < .001; S. epidermidis, P < .0001) and at 1- and 3-hour exposures at 37 degrees C (E. coli, P < .001; S. epidermidis, P < .0001). The bactericidal activity of the preservatives was markedly lower that that of 0.5% bupivacaine with preservatives (P < .0001).The bactericidal activity of 0.5% bupivacaine with preservatives is stronger at body temperature than at room temperature; the bactericidal activity may be due, to a large extent, to bupivacaine rather than to the preservatives; and S. aureus is more resistant to the bactericidal activity of bupivacaine than are S. epidermidis and E. coli." @default.
- W2073399032 created "2016-06-24" @default.
- W2073399032 creator A5001981906 @default.
- W2073399032 creator A5076221081 @default.
- W2073399032 creator A5081025557 @default.
- W2073399032 date "1997-03-01" @default.
- W2073399032 modified "2023-09-26" @default.
- W2073399032 title "Bactericidal activity of 0.5% bupivacaine with preservatives on microorganisms in the human skin flora" @default.
- W2073399032 cites W134518677 @default.
- W2073399032 cites W1916238341 @default.
- W2073399032 cites W1979944856 @default.
- W2073399032 cites W2032642391 @default.
- W2073399032 cites W2047592482 @default.
- W2073399032 cites W2054079326 @default.
- W2073399032 cites W2065916927 @default.
- W2073399032 cites W2072531749 @default.
- W2073399032 cites W2108041784 @default.
- W2073399032 cites W2121248816 @default.
- W2073399032 cites W2150290224 @default.
- W2073399032 cites W2169173518 @default.
- W2073399032 cites W2416033769 @default.
- W2073399032 doi "https://doi.org/10.1016/s1098-7339(06)80038-6" @default.
- W2073399032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9089861" @default.
- W2073399032 hasPublicationYear "1997" @default.
- W2073399032 type Work @default.
- W2073399032 sameAs 2073399032 @default.
- W2073399032 citedByCount "12" @default.
- W2073399032 countsByYear W20733990322012 @default.
- W2073399032 countsByYear W20733990322018 @default.
- W2073399032 countsByYear W20733990322019 @default.
- W2073399032 countsByYear W20733990322020 @default.
- W2073399032 crossrefType "journal-article" @default.
- W2073399032 hasAuthorship W2073399032A5001981906 @default.
- W2073399032 hasAuthorship W2073399032A5076221081 @default.
- W2073399032 hasAuthorship W2073399032A5081025557 @default.
- W2073399032 hasConcept C126322002 @default.
- W2073399032 hasConcept C2777397205 @default.
- W2073399032 hasConcept C2777949923 @default.
- W2073399032 hasConcept C2778022156 @default.
- W2073399032 hasConcept C2779489039 @default.
- W2073399032 hasConcept C2781328992 @default.
- W2073399032 hasConcept C31903555 @default.
- W2073399032 hasConcept C42219234 @default.
- W2073399032 hasConcept C4937899 @default.
- W2073399032 hasConcept C523546767 @default.
- W2073399032 hasConcept C54355233 @default.
- W2073399032 hasConcept C67031304 @default.
- W2073399032 hasConcept C71924100 @default.
- W2073399032 hasConcept C86803240 @default.
- W2073399032 hasConcept C89423630 @default.
- W2073399032 hasConceptScore W2073399032C126322002 @default.
- W2073399032 hasConceptScore W2073399032C2777397205 @default.
- W2073399032 hasConceptScore W2073399032C2777949923 @default.
- W2073399032 hasConceptScore W2073399032C2778022156 @default.
- W2073399032 hasConceptScore W2073399032C2779489039 @default.
- W2073399032 hasConceptScore W2073399032C2781328992 @default.
- W2073399032 hasConceptScore W2073399032C31903555 @default.
- W2073399032 hasConceptScore W2073399032C42219234 @default.
- W2073399032 hasConceptScore W2073399032C4937899 @default.
- W2073399032 hasConceptScore W2073399032C523546767 @default.
- W2073399032 hasConceptScore W2073399032C54355233 @default.
- W2073399032 hasConceptScore W2073399032C67031304 @default.
- W2073399032 hasConceptScore W2073399032C71924100 @default.
- W2073399032 hasConceptScore W2073399032C86803240 @default.
- W2073399032 hasConceptScore W2073399032C89423630 @default.
- W2073399032 hasLocation W20733990321 @default.
- W2073399032 hasLocation W20733990322 @default.
- W2073399032 hasOpenAccess W2073399032 @default.
- W2073399032 hasPrimaryLocation W20733990321 @default.
- W2073399032 hasRelatedWork W102773090 @default.
- W2073399032 hasRelatedWork W2007025525 @default.
- W2073399032 hasRelatedWork W2011659801 @default.
- W2073399032 hasRelatedWork W2073399032 @default.
- W2073399032 hasRelatedWork W2410131861 @default.
- W2073399032 hasRelatedWork W2603132479 @default.
- W2073399032 hasRelatedWork W2736636700 @default.
- W2073399032 hasRelatedWork W3024620619 @default.
- W2073399032 hasRelatedWork W4200017750 @default.
- W2073399032 hasRelatedWork W4242359208 @default.
- W2073399032 isParatext "false" @default.
- W2073399032 isRetracted "false" @default.
- W2073399032 magId "2073399032" @default.
- W2073399032 workType "article" @default.