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• W2073399116 endingPage "199" @default.
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• W2073399116 abstract "Vasoactive intestinal polypeptide (VIP) is an immunomodulatory neuropeptide distributed in micturition pathways. VIP−/− mice exhibit altered bladder function and neurochemical properties in micturition pathways after cyclophosphamide (CYP)-induced cystitis. Given VIP’s role as an anti-inflammatory mediator, we hypothesized that VIP−/− mice would exhibit enhanced inflammatory mediator expression after cystitis. A mouse inflammatory cytokine and receptor RT2 profiler array was used to determine regulated transcripts in the urinary bladder of wild type (WT) and VIP−/− mice with or without CYP-induced cystitis (150 mg/kg; i.p.; 48 h). Four binary comparisons were made: WT control versus CYP treatment (48 h), VIP−/− control versus CYP treatment (48 h), WT control versus VIP−/− control, and WT with CYP treatment (48 h) versus VIP−/− with CYP treatment (48 h). The genes presented represent (1) greater than 1.5-fold change in either direction and (2) the p value is less than 0.05 for the comparison being made. Several regulated genes were validated using enzyme-linked immunoassays including IL-1β and CXCL1. CYP treatment significantly (p ≤ 0.001) increased expression of CXCL1 and IL-1β in the urinary bladder of WT and VIP−/− mice, but expression in VIP−/− mice with CYP treatment was significantly (p ≤ 0.001) greater (4.2- to 13-fold increase) than that observed in WT urinary bladder (3.6- to 5-fold increase). The data suggest that in VIP−/− mice with bladder inflammation, inflammatory mediators are increased above that observed in WT with CYP. This shift in balance may contribute to increased bladder dysfunction in VIP−/− mice with bladder inflammation and altered neurochemical expression in micturition pathways." @default.
• W2073399116 created "2016-06-24" @default.
• W2073399116 creator A5002468639 @default.
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• W2073399116 date "2008-05-16" @default.
• W2073399116 modified "2023-10-10" @default.
• W2073399116 title "Exaggerated Expression of Inflammatory Mediators in Vasoactive Intestinal Polypeptide Knockout (VIP−/−) Mice with Cyclophosphamide (CYP)-Induced Cystitis" @default.
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• W2073399116 doi "https://doi.org/10.1007/s12031-008-9084-4" @default.
• W2073399116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2695563" @default.
• W2073399116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18483878" @default.
• W2073399116 hasPublicationYear "2008" @default.

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