Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073399285> ?p ?o ?g. }
- W2073399285 endingPage "49" @default.
- W2073399285 startingPage "42" @default.
- W2073399285 abstract "Abstract: This study was performed to evaluate the effect of melatonin on methanol‐induced liver injury. We evaluated the levels of malondialdehyde (MDA), protein carbonylation (PC), myeloperoxidase (MPO) activities and to assess lipid peroxidation, protein oxidation, neutrophil accumulation and nitrite which is a stable end product of nitric oxide respectively. We also studied superoxide dismutase, catalase, and glutathione peroxidase activities of liver tissue to evaluate the changes in the antioxidant status. Histopathological alterations were also determined. The experiment was performed on Wistar rats, which received intragastric 3 g/kg methanol as a 50% solution in isotonic saline once. After 6 and 24 hr all the drug received and intoxicated rats were killed under anesthesia. Pretreatment with melatonin (10 mg/kg) decreased the MDA levels significantly, restored the PC levels to the control, prevented the increase of nitrite level and MPO activity significantly and reversed to the control levels, prevented the reduction in all of the antioxidant enzyme activities. Additionally in melatonin treated group piecemeal necrosis, lobular lytic necrosis, and portal inflammation returned to normal histologic appearances when compared with methanol administration. In conclusion, melatonin has protective effects against methanol‐induced hepatic injury." @default.
- W2073399285 created "2016-06-24" @default.
- W2073399285 creator A5001486665 @default.
- W2073399285 creator A5019675478 @default.
- W2073399285 creator A5042504655 @default.
- W2073399285 creator A5055964298 @default.
- W2073399285 creator A5060269124 @default.
- W2073399285 creator A5063265556 @default.
- W2073399285 creator A5070633442 @default.
- W2073399285 date "2007-04-13" @default.
- W2073399285 modified "2023-10-16" @default.
- W2073399285 title "Melatonin improves methanol intoxication-induced oxidative liver injury in rats" @default.
- W2073399285 cites W1775749144 @default.
- W2073399285 cites W1966111215 @default.
- W2073399285 cites W1971060562 @default.
- W2073399285 cites W1972259716 @default.
- W2073399285 cites W1981900811 @default.
- W2073399285 cites W1984098308 @default.
- W2073399285 cites W1991757351 @default.
- W2073399285 cites W1993423345 @default.
- W2073399285 cites W2001326822 @default.
- W2073399285 cites W2005592098 @default.
- W2073399285 cites W2005986677 @default.
- W2073399285 cites W2019617678 @default.
- W2073399285 cites W2020709143 @default.
- W2073399285 cites W2022088901 @default.
- W2073399285 cites W2032813038 @default.
- W2073399285 cites W2035512890 @default.
- W2073399285 cites W2044994896 @default.
- W2073399285 cites W2046262166 @default.
- W2073399285 cites W2047716330 @default.
- W2073399285 cites W2050154615 @default.
- W2073399285 cites W2052868303 @default.
- W2073399285 cites W2059177685 @default.
- W2073399285 cites W2072739036 @default.
- W2073399285 cites W2072772681 @default.
- W2073399285 cites W2080847007 @default.
- W2073399285 cites W2081758047 @default.
- W2073399285 cites W2084416333 @default.
- W2073399285 cites W2085472280 @default.
- W2073399285 cites W2085651394 @default.
- W2073399285 cites W2124124560 @default.
- W2073399285 cites W2127137167 @default.
- W2073399285 cites W2133909568 @default.
- W2073399285 cites W2148071155 @default.
- W2073399285 cites W2159305277 @default.
- W2073399285 cites W2159598985 @default.
- W2073399285 cites W2166200602 @default.
- W2073399285 cites W2273023265 @default.
- W2073399285 cites W2323516874 @default.
- W2073399285 cites W4205407119 @default.
- W2073399285 doi "https://doi.org/10.1111/j.1600-079x.2007.00441.x" @default.
- W2073399285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17614834" @default.
- W2073399285 hasPublicationYear "2007" @default.
- W2073399285 type Work @default.
- W2073399285 sameAs 2073399285 @default.
- W2073399285 citedByCount "30" @default.
- W2073399285 countsByYear W20733992852012 @default.
- W2073399285 countsByYear W20733992852013 @default.
- W2073399285 countsByYear W20733992852016 @default.
- W2073399285 countsByYear W20733992852017 @default.
- W2073399285 countsByYear W20733992852018 @default.
- W2073399285 countsByYear W20733992852019 @default.
- W2073399285 countsByYear W20733992852020 @default.
- W2073399285 countsByYear W20733992852022 @default.
- W2073399285 countsByYear W20733992852023 @default.
- W2073399285 crossrefType "journal-article" @default.
- W2073399285 hasAuthorship W2073399285A5001486665 @default.
- W2073399285 hasAuthorship W2073399285A5019675478 @default.
- W2073399285 hasAuthorship W2073399285A5042504655 @default.
- W2073399285 hasAuthorship W2073399285A5055964298 @default.
- W2073399285 hasAuthorship W2073399285A5060269124 @default.
- W2073399285 hasAuthorship W2073399285A5063265556 @default.
- W2073399285 hasAuthorship W2073399285A5070633442 @default.
- W2073399285 hasConcept C126322002 @default.
- W2073399285 hasConcept C134018914 @default.
- W2073399285 hasConcept C185592680 @default.
- W2073399285 hasConcept C203565725 @default.
- W2073399285 hasConcept C2775838275 @default.
- W2073399285 hasConcept C2776151105 @default.
- W2073399285 hasConcept C2776637226 @default.
- W2073399285 hasConcept C2776914184 @default.
- W2073399285 hasConcept C2778004101 @default.
- W2073399285 hasConcept C2778182776 @default.
- W2073399285 hasConcept C2778401633 @default.
- W2073399285 hasConcept C2778760513 @default.
- W2073399285 hasConcept C2778979269 @default.
- W2073399285 hasConcept C2780829032 @default.
- W2073399285 hasConcept C519581460 @default.
- W2073399285 hasConcept C55493867 @default.
- W2073399285 hasConcept C71924100 @default.
- W2073399285 hasConcept C98274493 @default.
- W2073399285 hasConceptScore W2073399285C126322002 @default.
- W2073399285 hasConceptScore W2073399285C134018914 @default.
- W2073399285 hasConceptScore W2073399285C185592680 @default.
- W2073399285 hasConceptScore W2073399285C203565725 @default.
- W2073399285 hasConceptScore W2073399285C2775838275 @default.
- W2073399285 hasConceptScore W2073399285C2776151105 @default.