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- W2073399650 abstract "To determine the antioxidant role of Ginkgo biloba (GB) in preventing radiation-induced cataracts in the lens after total-cranium irradiation of rats with a single radiation dose of 5 Gy. Sprague-Dawley rats were randomly divided into three groups. Group 1 received neither GB nor irradiation (control group). Group 2 was exposed to total-cranium irradiation of 5 Gy in a single dose [radiation therapy (RT) Group], and group 3 received total cranium irradiation from a cobalt-60 teletherapy unit, plus 40 mg/kg per day GB (RT+GB group). At the end of the tenth day, the rats were killed and their eyes were enucleated to measure the antioxidant enzymes, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the lipid peroxidation level [malondialdehyde (MDA)]. Irradiation significantly increased both the MDA level and the activity of GSH-Px, and significantly decreased the activity of SOD in the rat lenses. GB supplementation significantly increased the activities of SOD and GSH-Px enzymes and significantly decreased the MDA level. Total cranium irradiation of 5 Gy in a single dose promoted cataract formation, and GB supplementation protected the lenses from radiation-induced cataracts. We suggest that Ginkgo biloba is an antioxidant that protects the rat lens from radiation-induced cataracts." @default.
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- W2073399650 date "2004-09-01" @default.
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- W2073399650 title "Effects of Oral Ginkgo biloba Supplementation on Cataract Formation and Oxidative Stress Occurring in Lenses of Rats Exposed to Total Cranium Radiotherapy" @default.
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- W2073399650 doi "https://doi.org/10.1007/s10384-004-0101-z" @default.
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