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• W2073399685 startingPage "1459" @default.
• W2073399685 abstract "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) is a membrane-bound cytokine molecule that belongs to the family of tumor necrosis factor (TNF). Members of this family share diverse biological effects, including induction of apoptosis and/or promotion of cell survival. Identification of TRAIL has generated considerable enthusiasm for its ability to induce apoptotic cell death in a variety of tumor cells, by engaging the death receptors TRAIL-R1/DR4 and TRAIL-R2/DR5, while sparing most normal cells. Beside its anticancer activity, several studies have suggested a role for endogenously expressed TRAIL in hemopoiesis. In this review, we summarize the knowledge about the different lineage-specific roles of TRAIL and its receptors in hemopoiesis regulation. Moreover, the complex interplay among the signaling pathways triggered by TRAIL/TRAIL-receptors in myeloid cells is discussed in some detail." @default.
• W2073399685 created "2016-06-24" @default.
• W2073399685 creator A5027331275 @default.
• W2073399685 creator A5034568556 @default.
• W2073399685 creator A5040231414 @default.
• W2073399685 creator A5075079041 @default.
• W2073399685 date "2006-01-01" @default.
• W2073399685 modified "2023-09-25" @default.
• W2073399685 title "TRAIL, caspases and maturation of normal and leukemic myeloid precursors" @default.
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