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- W2073405263 endingPage "72" @default.
- W2073405263 startingPage "58" @default.
- W2073405263 abstract "Pancreatic beta-cells possess an inherent ability to generate oscillatory signals that trigger insulin release. Coordination of the secretory activity among beta-cells results in pulsatile insulin secretion from the pancreas, which is considered important for the action of the hormone in the target tissues. This review focuses on the mechanisms underlying oscillatory control of insulin secretion at the level of the individual beta-cell. Recent studies have demonstrated that oscillations of the cytoplasmic Ca(2+) concentration are synchronized with oscillations in beta-cell metabolism, intracellular cAMP concentration, phospholipase C activity and plasma membrane phosphoinositide lipid concentrations. There are complex interdependencies between the different messengers and signalling pathways that contribute to amplitude regulation and shaping of the insulin secretory response to nutrient stimuli and neurohormonal modulators. Several of these pathways may be important pharmacological targets for improving pulsatile insulin secretion in type 2 diabetes." @default.
- W2073405263 created "2016-06-24" @default.
- W2073405263 creator A5020082293 @default.
- W2073405263 creator A5055074357 @default.
- W2073405263 date "2009-01-01" @default.
- W2073405263 modified "2023-10-16" @default.
- W2073405263 title "Oscillatory control of insulin secretion" @default.
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