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• W2073406862 startingPage "12471" @default.
• W2073406862 abstract "Divalent metal ions, such as Mg 2+ , are generally required for tertiary structure formation in RNA. Although the role of Mg 2+ binding in RNA-folding equilibria has been studied extensively, little is known about the role of Mg 2+ in RNA-folding kinetics. In this paper, we explore the effect of Mg 2+ on the rate-limiting step in the kinetic folding pathway of the Tetrahymen a ribozyme. Analysis of these data reveals the presence of a Mg 2+ -stabilized kinetic trap that slows folding at higher Mg 2+ concentrations. Thus, the Tetrahymena ribozyme folds with an optimal rate at 2 mM Mg 2+ , just above the concentration required for stable structure formation. These results suggest that thermodynamic and kinetic folding of RNA are cooptimized at a Mg 2+ concentration that is sufficient to stabilize the folded form but low enough to avoid kinetic traps and misfolding." @default.
• W2073406862 created "2016-06-24" @default.
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• W2073406862 date "1999-10-26" @default.
• W2073406862 modified "2023-10-06" @default.
• W2073406862 title "An optimal Mg ²⁺ concentration for kinetic folding of the <i>Tetrahymena</i> ribozyme" @default.
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• W2073406862 doi "https://doi.org/10.1073/pnas.96.22.12471" @default.
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