FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073407655> ?p ?o ?g. }

• W2073407655 endingPage "171" @default.
• W2073407655 startingPage "159" @default.
• W2073407655 abstract "Summary Most clinical isolates of Streptococcus pneumoniae consist of heterogeneous populations of at least two colony phenotypes, opaque and transparent, selected for in the bloodstream and nasopharynx, respectively. Microarray analysis revealed 24 orfs that demonstrated differences in expression greater than twofold between variants of independent strains. Twenty‐one of these showed increased expression in the transparent variants, including 11 predicted to be involved in sugar metabolism. A single genomic region contains seven of these loci including the gene that encodes the neuraminidase, NanA. In contrast to previous studies, there was no contribution of NanA to adherence of S. pneumoniae to epithelial cells or colonization in an animal model. However, we observed NanA‐dependent desialylation of human airway components that bind to the organism and may mediate bacterial clearance. Targets of desialylation included human lactoferrin, secretory component, and IgA2 that were shown to be present on the surface of the pneumococcus in vivo during pneumococcal pneumonia. The efficiency of desialylation was increased in the transparent variants and enhanced for host proteins binding to the surface of S. pneumoniae . Because deglycosylation affects the function of many host proteins, NanA may contribute to a protease‐independent mechanism to modify bound targets and facilitate enhanced survival of the bacterium." @default.
• W2073407655 created "2016-06-24" @default.
• W2073407655 creator A5011990703 @default.
• W2073407655 creator A5012501240 @default.
• W2073407655 creator A5024704076 @default.
• W2073407655 creator A5032339145 @default.
• W2073407655 creator A5034634166 @default.
• W2073407655 creator A5037376197 @default.
• W2073407655 creator A5066405485 @default.
• W2073407655 creator A5083592961 @default.
• W2073407655 creator A5088488493 @default.
• W2073407655 date "2004-08-03" @default.
• W2073407655 modified "2023-10-16" @default.
• W2073407655 title "Phase variable desialylation of host proteins that bind to Streptococcus pneumoniae in vivo and protect the airway" @default.
• W2073407655 cites W1508637059 @default.
• W2073407655 cites W1590971388 @default.
• W2073407655 cites W1623853610 @default.
• W2073407655 cites W1799665405 @default.
• W2073407655 cites W1827417957 @default.
• W2073407655 cites W1831821781 @default.
• W2073407655 cites W1848813826 @default.
• W2073407655 cites W1873318425 @default.
• W2073407655 cites W1973283944 @default.
• W2073407655 cites W1979131726 @default.
• W2073407655 cites W1987872384 @default.
• W2073407655 cites W2050722710 @default.
• W2073407655 cites W2054664792 @default.
• W2073407655 cites W2055507506 @default.
• W2073407655 cites W2064259891 @default.
• W2073407655 cites W2070088956 @default.
• W2073407655 cites W2070627443 @default.
• W2073407655 cites W2083495565 @default.
• W2073407655 cites W2088569914 @default.
• W2073407655 cites W2093717213 @default.
• W2073407655 cites W2095730944 @default.
• W2073407655 cites W2097506670 @default.
• W2073407655 cites W2101272466 @default.
• W2073407655 cites W2102621745 @default.
• W2073407655 cites W2104196974 @default.
• W2073407655 cites W2106850668 @default.
• W2073407655 cites W2107277218 @default.
• W2073407655 cites W2108205511 @default.
• W2073407655 cites W2108360478 @default.
• W2073407655 cites W2111281901 @default.
• W2073407655 cites W2113403119 @default.
• W2073407655 cites W2115908628 @default.
• W2073407655 cites W2119569074 @default.
• W2073407655 cites W2126132109 @default.
• W2073407655 cites W2129453055 @default.
• W2073407655 cites W2130754971 @default.
• W2073407655 cites W2131574907 @default.
• W2073407655 cites W2136283759 @default.
• W2073407655 cites W2139284625 @default.
• W2073407655 cites W2142581528 @default.
• W2073407655 cites W2144240057 @default.
• W2073407655 cites W2145232478 @default.
• W2073407655 cites W2145707122 @default.
• W2073407655 cites W2148637247 @default.
• W2073407655 cites W2157325299 @default.
• W2073407655 cites W2162339585 @default.
• W2073407655 cites W2163188120 @default.
• W2073407655 cites W2163412067 @default.
• W2073407655 cites W2164033870 @default.
• W2073407655 cites W2167435540 @default.
• W2073407655 cites W2170180435 @default.
• W2073407655 cites W2188055647 @default.
• W2073407655 cites W2329109548 @default.
• W2073407655 cites W40840948 @default.
• W2073407655 cites W95293157 @default.
• W2073407655 doi "https://doi.org/10.1111/j.1365-2958.2004.04252.x" @default.
• W2073407655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15458413" @default.
• W2073407655 hasPublicationYear "2004" @default.
• W2073407655 type Work @default.
• W2073407655 sameAs 2073407655 @default.
• W2073407655 citedByCount "114" @default.
• W2073407655 countsByYear W20734076552012 @default.
• W2073407655 countsByYear W20734076552013 @default.
• W2073407655 countsByYear W20734076552014 @default.
• W2073407655 countsByYear W20734076552015 @default.
• W2073407655 countsByYear W20734076552016 @default.
• W2073407655 countsByYear W20734076552017 @default.
• W2073407655 countsByYear W20734076552018 @default.
• W2073407655 countsByYear W20734076552019 @default.
• W2073407655 countsByYear W20734076552020 @default.
• W2073407655 countsByYear W20734076552021 @default.
• W2073407655 countsByYear W20734076552022 @default.
• W2073407655 countsByYear W20734076552023 @default.
• W2073407655 crossrefType "journal-article" @default.
• W2073407655 hasAuthorship W2073407655A5011990703 @default.
• W2073407655 hasAuthorship W2073407655A5012501240 @default.
• W2073407655 hasAuthorship W2073407655A5024704076 @default.
• W2073407655 hasAuthorship W2073407655A5032339145 @default.
• W2073407655 hasAuthorship W2073407655A5034634166 @default.
• W2073407655 hasAuthorship W2073407655A5037376197 @default.
• W2073407655 hasAuthorship W2073407655A5066405485 @default.
• W2073407655 hasAuthorship W2073407655A5083592961 @default.
• W2073407655 hasAuthorship W2073407655A5088488493 @default.
• W2073407655 hasBestOaLocation W20734076551 @default.

• next