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• W2073408281 abstract "ObjectiveOvarian reserve testing is utilized to predict the reproductive potential of infertility patients. This study investigated the relationship between abnormal ovarian reserve parameters and the diagnosis of aneuploid blastocysts.DesignRetrospective study.Materials and MethodsInfertility patients presented with abnormal ovarian reserve (n = 59) based on D3 FSH (>10mIU/ml) and/or AMH (≤1ng/ml). Trophectoderm biopsies were analyzed for comprehensive chromosome screening by mCGH (Reprogenetics) or SNP microarray (RMA-NJ) prior to vitrification. Only euploid blastocysts were warmed and transferred in a subsequent frozen blastocyst transfer. IRB approved consent was obtained.ResultsOverall the proportion of aneuploid blastocysts in patients with abnormal ovarian reserve was 66%, significantly higher than for 151 cycles in patients presenting with normal ovarian reserve (46%; P<0.01). Patients were further analyzed accordingly; Group A = D3 FSH >10mIU/ml and AMH ≤1ng/ml (n = 25 cycles), Group B = D3 FSH >10mIU/ml and AMH >1ng/ml (n = 34 cycles), Group C = AMH ≤1ng/ml and D3 FSH ≤10mIU/ml (n = 34 cycles). There were no significant differences between the groups in relation to maternal age (mean 38.9 years). Low AMH reflected a significantly lower number of oocytes retrieved (A = 10.6, B = 17.4 and C = 13.8; P<0.01) and a trend towards a lower number of blastocysts biopsied (A = 3.2, B = 4.6 and C = 3.5; ns). However, in relation to the proportion of aneuploid blastocysts a significant increase was observed only for Group A (77.2% versus B = 58.5% and C = 58.8%; P<0.05). Following transfer of euploid blastocysts there were no differences in outcomes including implantation rate with fetal cardiac activity (A = 76%, B = 71% and C = 69%; ns).ConclusionAbnormal ovarian reserve, in particular abnormal AMH is predictive of a higher incidence of chromosomally aneuploidy blastocysts. Once a blastocyst is identified as chromosomally euploid for transfer, implantation potential is equivalent independent of ovarian reserve parameters. ObjectiveOvarian reserve testing is utilized to predict the reproductive potential of infertility patients. This study investigated the relationship between abnormal ovarian reserve parameters and the diagnosis of aneuploid blastocysts. Ovarian reserve testing is utilized to predict the reproductive potential of infertility patients. This study investigated the relationship between abnormal ovarian reserve parameters and the diagnosis of aneuploid blastocysts. DesignRetrospective study. Retrospective study. Materials and MethodsInfertility patients presented with abnormal ovarian reserve (n = 59) based on D3 FSH (>10mIU/ml) and/or AMH (≤1ng/ml). Trophectoderm biopsies were analyzed for comprehensive chromosome screening by mCGH (Reprogenetics) or SNP microarray (RMA-NJ) prior to vitrification. Only euploid blastocysts were warmed and transferred in a subsequent frozen blastocyst transfer. IRB approved consent was obtained. Infertility patients presented with abnormal ovarian reserve (n = 59) based on D3 FSH (>10mIU/ml) and/or AMH (≤1ng/ml). Trophectoderm biopsies were analyzed for comprehensive chromosome screening by mCGH (Reprogenetics) or SNP microarray (RMA-NJ) prior to vitrification. Only euploid blastocysts were warmed and transferred in a subsequent frozen blastocyst transfer. IRB approved consent was obtained. ResultsOverall the proportion of aneuploid blastocysts in patients with abnormal ovarian reserve was 66%, significantly higher than for 151 cycles in patients presenting with normal ovarian reserve (46%; P<0.01). Patients were further analyzed accordingly; Group A = D3 FSH >10mIU/ml and AMH ≤1ng/ml (n = 25 cycles), Group B = D3 FSH >10mIU/ml and AMH >1ng/ml (n = 34 cycles), Group C = AMH ≤1ng/ml and D3 FSH ≤10mIU/ml (n = 34 cycles). There were no significant differences between the groups in relation to maternal age (mean 38.9 years). Low AMH reflected a significantly lower number of oocytes retrieved (A = 10.6, B = 17.4 and C = 13.8; P<0.01) and a trend towards a lower number of blastocysts biopsied (A = 3.2, B = 4.6 and C = 3.5; ns). However, in relation to the proportion of aneuploid blastocysts a significant increase was observed only for Group A (77.2% versus B = 58.5% and C = 58.8%; P<0.05). Following transfer of euploid blastocysts there were no differences in outcomes including implantation rate with fetal cardiac activity (A = 76%, B = 71% and C = 69%; ns). Overall the proportion of aneuploid blastocysts in patients with abnormal ovarian reserve was 66%, significantly higher than for 151 cycles in patients presenting with normal ovarian reserve (46%; P<0.01). Patients were further analyzed accordingly; Group A = D3 FSH >10mIU/ml and AMH ≤1ng/ml (n = 25 cycles), Group B = D3 FSH >10mIU/ml and AMH >1ng/ml (n = 34 cycles), Group C = AMH ≤1ng/ml and D3 FSH ≤10mIU/ml (n = 34 cycles). There were no significant differences between the groups in relation to maternal age (mean 38.9 years). Low AMH reflected a significantly lower number of oocytes retrieved (A = 10.6, B = 17.4 and C = 13.8; P<0.01) and a trend towards a lower number of blastocysts biopsied (A = 3.2, B = 4.6 and C = 3.5; ns). However, in relation to the proportion of aneuploid blastocysts a significant increase was observed only for Group A (77.2% versus B = 58.5% and C = 58.8%; P<0.05). Following transfer of euploid blastocysts there were no differences in outcomes including implantation rate with fetal cardiac activity (A = 76%, B = 71% and C = 69%; ns). ConclusionAbnormal ovarian reserve, in particular abnormal AMH is predictive of a higher incidence of chromosomally aneuploidy blastocysts. Once a blastocyst is identified as chromosomally euploid for transfer, implantation potential is equivalent independent of ovarian reserve parameters. Abnormal ovarian reserve, in particular abnormal AMH is predictive of a higher incidence of chromosomally aneuploidy blastocysts. Once a blastocyst is identified as chromosomally euploid for transfer, implantation potential is equivalent independent of ovarian reserve parameters." @default.
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• W2073408281 title "Abnormal ovarian reserve predicts a higher incidence of aneuploid blastocysts" @default.
• W2073408281 doi "https://doi.org/10.1016/j.fertnstert.2011.07.208" @default.
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